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CD160 molecule
Identifiers
Symbols CD160; BY55; FLJ46513; NK1; NK28
External IDs OMIM604463 MGI1860383 HomoloGene5122 GeneCards: CD160 Gene
RNA expression pattern
PBB GE CD160 207840 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11126 54215
Ensembl ENSG00000117281 ENSMUSG00000038304
UniProt O95971 Q8C9H4
RefSeq (mRNA) NM_007053 NM_018767
RefSeq (protein) NP_008984 NP_061237
Location (UCSC) Chr 1:
144.41 - 144.43 Mb
Chr 3:
96.89 - 96.9 Mb
PubMed search [1] [2]

CD160 antigen is a protein that in humans is encoded by the CD160 gene.[1][2][3]

CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.[3]

Contents

See also

References

  1. ^ Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (Oct 1998). "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes". J Immunol 161 (6): 2780-90. PMID 9743336.  
  2. ^ Agrawal S, Marquet J, Freeman GJ, Tawab A, Bouteiller PL, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A (Apr 1999). "Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells". J Immunol 162 (3): 1223-6. PMID 9973372.  
  3. ^ a b "Entrez Gene: CD160 CD160 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11126.  

Further reading

  • Bensussan A, Gluckman E, el Marsafy S, et al. (1994). "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity.". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9136–40. doi:10.1073/pnas.91.19.9136. PMID 8090781.  
  • Nikolova M, Marie-Cardine A, Boumsell L, Bensussan A (2002). "BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression.". Int. Immunol. 14 (5): 445–51. doi:10.1093/intimm/14.5.445. PMID 11978774.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tanaka J, Toubai T, Tsutsumi Y, et al. (2004). "Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells.". Blood 104 (3): 768–74. doi:10.1182/blood-2003-11-3870. PMID 15073036.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Barakonyi A, Rabot M, Marie-Cardine A, et al. (2004). "Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset.". J. Immunol. 173 (9): 5349–54. PMID 15494480.  
  • Abecassis S, Giustiniani J, Meyer N, et al. (2007). "Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation.". J. Invest. Dermatol. 127 (5): 1161–6. doi:10.1038/sj.jid.5700680. PMID 17218942.  
  • Giustiniani J, Marie-Cardine A, Bensussan A (2007). "A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity.". J. Immunol. 178 (3): 1293–300. PMID 17237375.  

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