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CD1d molecule

PDB rendering based on 1zt4.
Available structures
1zt4
Identifiers
Symbols CD1D; CD1A; MGC34622; R3
External IDs OMIM188410 MGI107674 HomoloGene1337 GeneCards: CD1D Gene
RNA expression pattern
PBB GE CD1D 205789 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 912 12479
Ensembl ENSG00000158473 ENSMUSG00000028076
UniProt P15813 Q91XK9
RefSeq (mRNA) NM_001766 NM_007639
RefSeq (protein) NP_001757 NP_031665
Location (UCSC) Chr 1:
156.42 - 156.42 Mb
Chr 3:
87.08 - 87.09 Mb
PubMed search [1] [2]


CD1d is a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules.

CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.

Nomenclature

  • CD1d is also known as R3G1

Further reading

  • Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules.". Curr. Opin. Immunol. 8 (1): 82–8. doi:10.1016/S0952-7915(96)80109-9. PMID 8729450.  
  • Joyce S (2001). "CD1d and natural T cells: how their properties jump-start the immune system.". Cell. Mol. Life Sci. 58 (3): 442–69. doi:10.1007/PL00000869. PMID 11315191.  
  • Sköld M, Behar SM (2003). "Role of CD1d-restricted NKT cells in microbial immunity.". Infect. Immun. 71 (10): 5447–55. doi:10.1128/IAI.71.10.5447-5455.2003. PMID 14500461.  
  • Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function.". Annu. Rev. Immunol. 22: 817–90. doi:10.1146/annurev.immunol.22.012703.104608. PMID 15032598.  
  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.  
  • Brutkiewicz RR (2006). "CD1d ligands: the good, the bad, and the ugly.". J. Immunol. 177 (2): 769–75. PMID 16818729.  
  • Blumberg RS, Terhorst C, Bleicher P, et al. (1991). "Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.". J. Immunol. 147 (8): 2518–24. PMID 1717564.  
  • Balk SP, Bleicher PA, Terhorst C (1989). "Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule.". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 252–6. doi:10.1073/pnas.86.1.252. PMID 2463622.  
  • Calabi F, Jarvis JM, Martin L, Milstein C (1989). "Two classes of CD1 genes.". Eur. J. Immunol. 19 (2): 285–92. doi:10.1002/eji.1830190211. PMID 2467814.  
  • Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes.". EMBO J. 8 (12): 3727–32. PMID 2583117.  
  • Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–8. doi:10.1073/pnas.83.23.9154. PMID 3097645.  
  • Balk SP, Burke S, Polischuk JE, et al. (1994). "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium.". Science 265 (5169): 259–62. doi:10.1126/science.7517575. PMID 7517575.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Kawano T, Cui J, Koezuka Y, et al. (1997). "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.". Science 278 (5343): 1626–9. doi:10.1126/science.278.5343.1626. PMID 9374463.  
  • Katabami S, Matsuura A, Chen HZ, et al. (1998). "Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes.". Immunogenetics 48 (1): 22–31. doi:10.1007/s002510050396. PMID 9601940.  
  • Somnay-Wadgaonkar K, Nusrat A, Kim HS, et al. (1999). "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form.". Int. Immunol. 11 (3): 383–92. doi:10.1093/intimm/11.3.383. PMID 10221650.  
  • Campbell NA, Kim HS, Blumberg RS, Mayer L (1999). "The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells.". J. Biol. Chem. 274 (37): 26259–65. doi:10.1074/jbc.274.37.26259. PMID 10473580.  
  • Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes.". Tissue Antigens 54 (2): 122–7. doi:10.1034/j.1399-0039.1999.540202.x. PMID 10488738.  

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