The Full Wiki

More info on CD22

CD22: Wikis

Advertisements
  
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
CD22 molecule
Identifiers
Symbols CD22; MGC130020; SIGLEC-2; SIGLEC2
External IDs OMIM107266 MGI88322 HomoloGene31052 GeneCards: CD22 Gene
RNA expression pattern
PBB GE CD22 38521 at tn.png
PBB GE CD22 204581 at tn.png
PBB GE CD22 217422 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 933 12483
Ensembl ENSG00000012124 ENSMUSG00000030577
UniProt P20273 Q3T9T5
RefSeq (mRNA) NM_001771 NM_001043317
RefSeq (protein) NP_001762 NP_001036782
Location (UCSC) Chr 19:
40.51 - 40.53 Mb
Chr 7:
30.57 - 30.59 Mb
PubMed search [1] [2]

CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[1] Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.

CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.

An immunotoxin, BL22, that targets this receptor is being tested at the NIH. [2]

External links

Interactions

CD22 has been shown to interact with Grb2,[3][4] PTPN6,[5][4][6][7][8] LYN,[3][6] SHC1[3] and INPP5D.[3]

References

  1. ^ Crocker PR, Clark EA, Filbin M, Gordon S, Jones Y, Kehrl JH, Kelm S, Le Douarin N, Powell L, Roder J, Schnaar RL, Sgroi DC, Stamenkovic K, Schauer R, Schachner M, van den Berg TK, van der Merwe PA, Watt SM, Varki A (1998). "Siglecs: a family of sialic-acid binding lectins". Glycobiology 8 (2): v. doi:10.1093/glycob/8.2.0. PMID 9498912.  
  2. ^ "BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia". ClinicalTrials.gov - U.S. National Institutes of Health. http://clinicaltrials.gov/ct/show/NCT00074048. Retrieved 2008-02-19.  
  3. ^ a b c d Poe, J C; Fujimoto M, Jansen P J, Miller A S, Tedder T F (Jun. 2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". J. Biol. Chem. (UNITED STATES) 275 (23): 17420–7. doi:10.1074/jbc.M001892200. ISSN 0021-9258. PMID 10748054.  
  4. ^ a b Otipoby, K L; Draves K E, Clark E A (Nov. 2001). "CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1". J. Biol. Chem. (United States) 276 (47): 44315–22. doi:10.1074/jbc.M105446200. ISSN 0021-9258. PMID 11551923.  
  5. ^ Blasioli, J; Paust S, Thomas M L (Jan. 1999). "Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22". J. Biol. Chem. (UNITED STATES) 274 (4): 2303–7. ISSN 0021-9258. PMID 9890995.  
  6. ^ a b Greer, S F; Justement L B (May. 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1". J. Immunol. (UNITED STATES) 162 (9): 5278–86. ISSN 0022-1767. PMID 10228003.  
  7. ^ Law, C L; Sidorenko S P, Chandran K A, Zhao Z, Shen S H, Fischer E H, Clark E A (Feb. 1996). "CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation". J. Exp. Med. (UNITED STATES) 183 (2): 547–60. ISSN 0022-1007. PMID 8627166.  
  8. ^ Adachi, T; Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T (Jul. 2001). "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates". J. Biol. Chem. (United States) 276 (28): 26648–55. doi:10.1074/jbc.M100997200. ISSN 0021-9258. PMID 11356834.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message