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CD226 molecule
Identifiers
Symbols CD226; DNAM-1; DNAM1; PTA1; TLiSA1
External IDs OMIM605397 MGI3039602 HomoloGene4787 GeneCards: CD226 Gene
RNA expression pattern
PBB GE CD226 207315 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10666 225825
Ensembl ENSG00000150637 ENSMUSG00000034028
UniProt Q15762 Q5DW69
RefSeq (mRNA) NM_006566 NM_001039148
RefSeq (protein) NP_006557 NP_001034237
Location (UCSC) Chr 18:
65.68 - 65.78 Mb
Chr 18:
89.33 - 89.4 Mb
PubMed search [1] [2]

CD226 (Cluster of Differentiation 226) is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.[1]

Contents

Structure and function

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,[2][3] and cross-linking CD226 with antibodies causes cellular activation.[1]

See also

References

  1. ^ a b "Entrez Gene: CD226 CD226 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10666.  
  2. ^ Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMID 12913096.  
  3. ^ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. PMID 15039383.  

Further reading

  • Shibuya A, Campbell D, Hannum C, et al. (1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.". Immunity 4 (6): 573–81. doi:10.1016/S1074-7613(00)70060-4. PMID 8673704.  
  • Shibuya K, Lanier LL, Phillips JH, et al. (2000). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.". Immunity 11 (5): 615–23. doi:10.1016/S1074-7613(00)80136-3. PMID 10591186.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kojima H, Kanada H, Shimizu S, et al. (2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells.". J. Biol. Chem. 278 (38): 36748–53. doi:10.1074/jbc.M300702200. PMID 12847109.  
  • Shibuya K, Shirakawa J, Kameyama T, et al. (2004). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation.". J. Exp. Med. 198 (12): 1829–39. doi:10.1084/jem.20030958. PMID 14676297.  
  • Reymond N, Imbert AM, Devilard E, et al. (2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions.". J. Exp. Med. 199 (10): 1331–41. doi:10.1084/jem.20032206. PMID 15136589.  
  • Ralston KJ, Hird SL, Zhang X, et al. (2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large.". J. Biol. Chem. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Pende D, Spaggiari GM, Marcenaro S, et al. (2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).". Blood 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144.  
  • Pende D, Bottino C, Castriconi R, et al. (2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.". Mol. Immunol. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800.  
  • Tao D, Shangwu L, Qun W, et al. (2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus.". J. Immunol. 174 (3): 1281–90. PMID 15661884.  
  • Ma D, Sun Y, Lin D, et al. (2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization.". Eur. J. Haematol. 74 (3): 228–40. doi:10.1111/j.1600-0609.2004.00345.x. PMID 15693793.  
  • Storojeva I, Boulay JL, Ballabeni P, et al. (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer.". Oncology 68 (2-3): 246–55. doi:10.1159/000086781. PMID 16015041.  
  • Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.". J. Biol. Chem. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868.  
  • Jian JL, Zhu CS, Xu ZW, et al. (2006). "Identification and characterization of the CD226 gene promoter.". J. Biol. Chem. 281 (39): 28731–6. doi:10.1074/jbc.M601786200. PMID 16887814.  
  • Ye X, Zhang Z, Jiang Y, et al. (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients.". Viral Immunol. 19 (3): 576–81. doi:10.1089/vim.2006.19.576. PMID 16987076.  
  • El-Sherbiny YM, Meade JL, Holmes TD, et al. (2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells.". Cancer Res. 67 (18): 8444–9. doi:10.1158/0008-5472.CAN-06-4230. PMID 17875681.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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