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CD226: Wikis


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CD226 molecule
Symbols CD226; DNAM-1; DNAM1; PTA1; TLiSA1
External IDs OMIM605397 MGI3039602 HomoloGene4787 GeneCards: CD226 Gene
RNA expression pattern
PBB GE CD226 207315 at tn.png
More reference expression data
Species Human Mouse
Entrez 10666 225825
Ensembl ENSG00000150637 ENSMUSG00000034028
UniProt Q15762 Q5DW69
RefSeq (mRNA) NM_006566 NM_001039148
RefSeq (protein) NP_006557 NP_001034237
Location (UCSC) Chr 18:
65.68 - 65.78 Mb
Chr 18:
89.33 - 89.4 Mb
PubMed search [1] [2]

CD226 (Cluster of Differentiation 226) is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.[1]


Structure and function

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,[2][3] and cross-linking CD226 with antibodies causes cellular activation.[1]

See also


  1. ^ a b "Entrez Gene: CD226 CD226 molecule".  
  2. ^ Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMID 12913096.  
  3. ^ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. PMID 15039383.  

Further reading

  • Shibuya A, Campbell D, Hannum C, et al. (1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.". Immunity 4 (6): 573–81. doi:10.1016/S1074-7613(00)70060-4. PMID 8673704.  
  • Shibuya K, Lanier LL, Phillips JH, et al. (2000). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.". Immunity 11 (5): 615–23. doi:10.1016/S1074-7613(00)80136-3. PMID 10591186.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kojima H, Kanada H, Shimizu S, et al. (2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells.". J. Biol. Chem. 278 (38): 36748–53. doi:10.1074/jbc.M300702200. PMID 12847109.  
  • Shibuya K, Shirakawa J, Kameyama T, et al. (2004). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation.". J. Exp. Med. 198 (12): 1829–39. doi:10.1084/jem.20030958. PMID 14676297.  
  • Reymond N, Imbert AM, Devilard E, et al. (2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions.". J. Exp. Med. 199 (10): 1331–41. doi:10.1084/jem.20032206. PMID 15136589.  
  • Ralston KJ, Hird SL, Zhang X, et al. (2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large.". J. Biol. Chem. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Pende D, Spaggiari GM, Marcenaro S, et al. (2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).". Blood 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144.  
  • Pende D, Bottino C, Castriconi R, et al. (2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.". Mol. Immunol. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800.  
  • Tao D, Shangwu L, Qun W, et al. (2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus.". J. Immunol. 174 (3): 1281–90. PMID 15661884.  
  • Ma D, Sun Y, Lin D, et al. (2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization.". Eur. J. Haematol. 74 (3): 228–40. doi:10.1111/j.1600-0609.2004.00345.x. PMID 15693793.  
  • Storojeva I, Boulay JL, Ballabeni P, et al. (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer.". Oncology 68 (2-3): 246–55. doi:10.1159/000086781. PMID 16015041.  
  • Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.". J. Biol. Chem. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868.  
  • Jian JL, Zhu CS, Xu ZW, et al. (2006). "Identification and characterization of the CD226 gene promoter.". J. Biol. Chem. 281 (39): 28731–6. doi:10.1074/jbc.M601786200. PMID 16887814.  
  • Ye X, Zhang Z, Jiang Y, et al. (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients.". Viral Immunol. 19 (3): 576–81. doi:10.1089/vim.2006.19.576. PMID 16987076.  
  • El-Sherbiny YM, Meade JL, Holmes TD, et al. (2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells.". Cancer Res. 67 (18): 8444–9. doi:10.1158/0008-5472.CAN-06-4230. PMID 17875681.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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