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CD248 molecule, endosialin
Identifiers
Symbols CD248; CD164L1; MGC119478; MGC119479; TEM1
External IDs OMIM606064 MGI1917695 HomoloGene10699 GeneCards: CD248 Gene
RNA expression pattern
PBB GE CD248 219025 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57124 70445
Ensembl ENSG00000174807 ENSMUSG00000056481
UniProt Q9HCU0 Q91V98
RefSeq (mRNA) NM_020404 NM_054042
RefSeq (protein) NP_065137 NP_473383
Location (UCSC) Chr 11:
65.84 - 65.84 Mb
Chr 19:
5.07 - 5.07 Mb
PubMed search [1] [2]

Endosialin is a protein that in humans is encoded by the CD248 gene.[1][2][3]

Contents

See also

References

  1. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science 289 (5482): 1197-202. PMID 10947988.  
  2. ^ Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC (May 2001). "Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium". J Biol Chem 276 (10): 7408-14. doi:10.1074/jbc.M009604200. PMID 11084048.  
  3. ^ "Entrez Gene: CD248 CD248 molecule, endosialin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57124.  

Further reading

  • Rettig WJ, Garin-Chesa P, Healey JH, et al. (1992). "Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer.". Proc. Natl. Acad. Sci. U.S.A. 89 (22): 10832–6. doi:10.1073/pnas.89.22.10832. PMID 1438285.  
  • Opavsky R, Haviernik P, Jurkovicova D, et al. (2001). "Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.". J. Biol. Chem. 276 (42): 38795–807. doi:10.1074/jbc.M105241200. PMID 11489895.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Brady J, Neal J, Sadakar N, Gasque P (2005). "Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors.". J. Neuropathol. Exp. Neurol. 63 (12): 1274–83. PMID 15624764.  
  • MacFadyen JR, Haworth O, Roberston D, et al. (2005). "Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium.". FEBS Lett. 579 (12): 2569–75. doi:10.1016/j.febslet.2005.03.071. PMID 15862292.  
  • Dolznig H, Schweifer N, Puri C, et al. (2006). "Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin.". Cancer Immun. 5: 10. PMID 16076089.  
  • Tomkowicz B, Rybinski K, Foley B, et al. (2008). "Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration.". Proc. Natl. Acad. Sci. U.S.A. 104 (46): 17965–70. doi:10.1073/pnas.0705647104. PMID 17986615.  

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