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Tumor necrosis factor receptor superfamily, member 8
Identifiers
Symbols TNFRSF8; CD30; D1S166E; KI-1
External IDs OMIM153243 MGI99908 HomoloGene949 GeneCards: TNFRSF8 Gene
RNA expression pattern
PBB GE TNFRSF8 206729 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 943 21941
Ensembl ENSG00000120949 ENSMUSG00000028602
UniProt P28908 Q60846
RefSeq (mRNA) NM_001243 NM_009401
RefSeq (protein) NP_001234 NP_033427
Location (UCSC) Chr 1:
12.05 - 12.13 Mb
Chr 4:
144.54 - 144.58 Mb
PubMed search [1] [2]

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.

This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[1]

CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus is a useful marker in distinguishing between these germ cell tumors.[2] CD30 and CD15 are also expressed on classical Hodgkin Lymphoma cells [3].

Contents

Interactions

CD30 has been shown to interact with TRAF5,[4] TRAF1,[5] TRAF2[4][5] and TRAF3.[5]

References

  1. ^ "Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=943.  
  2. ^ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]" (in Chinese). Zhonghua Bing Li Xue Za Zhi 34 (11): 711–5. PMID 16536313.  
  3. ^ http://www.ncbi.nlm.nih.gov/pubmed/12527929
  4. ^ a b Aizawa, S; Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan. 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. (UNITED STATES) 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. ISSN 0021-9258. PMID 8999898.  
  5. ^ a b c Ansieau, S; Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss H J (Nov. 1996). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 14053–8. doi:10.1073/pnas.93.24.14053. ISSN 0027-8424. PMID 8943059.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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