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Tumor necrosis factor receptor superfamily, member 8
Identifiers
Symbols	TNFRSF8; CD30; D1S166E; KI-1
External IDs	OMIM: 153243 MGI: 99908 HomoloGene: 949 GeneCards: TNFRSF8 Gene
Gene ontology Molecular function • transmembrane receptor activity • protein binding Cellular component • membrane • integral to membrane Biological process • signal transduction • negative regulation of cell proliferation
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	943	21941
Ensembl	ENSG00000120949	ENSMUSG00000028602
UniProt	P28908	Q60846
RefSeq (mRNA)	NM_001243	NM_009401
RefSeq (protein)	NP_001234	NP_033427
Location (UCSC)	Chr 1: 12.05 - 12.13 Mb	Chr 4: 144.54 - 144.58 Mb
PubMed search	[1]	[2]

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.

This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[1]

CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus is a useful marker in distinguishing between these germ cell tumors.^[2] CD30 and CD15 are also expressed on classical Hodgkin Lymphoma cells ^[3].

Interactions

CD30 has been shown to interact with TRAF5,^[4] TRAF1,^[5] TRAF2^[4][5] and TRAF3.^[5]

References

Further reading

External links

• MeSH CD30+Antigens

This article incorporates text from the United States National Library of Medicine, which is in the public domain.