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CD300a molecule
Identifiers
Symbols CD300A; CMRF-35-H9; CMRF-35H; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC2; IRp60
External IDs OMIM606790 MGI2443411 HomoloGene48514 GeneCards: CD300A Gene
RNA expression pattern
PBB GE CD300A 209933 s at tn.png
PBB GE CD300A 217078 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11314 217303
Ensembl ENSG00000167851 ENSMUSG00000034652
UniProt Q9UGN4 n/a
RefSeq (mRNA) NM_007261 NM_170758
RefSeq (protein) NP_009192 NP_739564
Location (UCSC) Chr 17:
69.97 - 69.99 Mb
Chr 11:
114.71 - 114.72 Mb
PubMed search [1] [2]

CD300A (Cluster of Differentiation 300A) is a human gene.[1]

The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).[supplied by OMIM][1]

Contents

References

See also

Further reading

  • Clark GJ, Fitzpatrick S, Kuo B, et al. (2003). "CMRF-35A, CMRF-35H: potential new CD.". J. Biol. Regul. Homeost. Agents 16 (3): 233–5. PMID 12456026.  
  • Alvarez Y, Tang X, Coligan JE, Borrego F (2007). "The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.". Mol. Immunol. 45 (1): 253–8. doi:10.1016/j.molimm.2007.05.006. PMID 17588661.  
  • Bachelet I, Munitz A, Moretta A, et al. (2006). "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.". J. Immunol. 175 (12): 7989–95. PMID 16339535.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Clark GJ, Green BJ, Hart DN (2000). "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17.". Tissue Antigens 55 (2): 101–9. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781.  
  • Cantoni C, Bottino C, Augugliaro R, et al. (1999). "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.". Eur. J. Immunol. 29 (10): 3148–59. doi:10.1002/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L. PMID 10540326.  
  • Green BJ, Clark GJ, Hart DN (1998). "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.". Int. Immunol. 10 (7): 891–9. doi:10.1093/intimm/10.7.891. PMID 9701027.  
  • Jackson DG, Hart DN, Starling G, Bell JI (1992). "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor.". Eur. J. Immunol. 22 (5): 1157–63. doi:10.1002/eji.1830220508. PMID 1349532.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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