The Full Wiki

More info on CD300A

CD300A: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

CD300a molecule
Symbols CD300A; CMRF-35-H9; CMRF-35H; CMRF35H; CMRF35H9; IGSF12; IRC1; IRC2; IRp60
External IDs OMIM606790 MGI2443411 HomoloGene48514 GeneCards: CD300A Gene
RNA expression pattern
PBB GE CD300A 209933 s at tn.png
PBB GE CD300A 217078 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11314 217303
Ensembl ENSG00000167851 ENSMUSG00000034652
UniProt Q9UGN4 n/a
RefSeq (mRNA) NM_007261 NM_170758
RefSeq (protein) NP_009192 NP_739564
Location (UCSC) Chr 17:
69.97 - 69.99 Mb
Chr 11:
114.71 - 114.72 Mb
PubMed search [1] [2]

CD300A (Cluster of Differentiation 300A) is a human gene.[1]

The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).[supplied by OMIM][1]



See also

Further reading

  • Clark GJ, Fitzpatrick S, Kuo B, et al. (2003). "CMRF-35A, CMRF-35H: potential new CD.". J. Biol. Regul. Homeost. Agents 16 (3): 233–5. PMID 12456026.  
  • Alvarez Y, Tang X, Coligan JE, Borrego F (2007). "The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling.". Mol. Immunol. 45 (1): 253–8. doi:10.1016/j.molimm.2007.05.006. PMID 17588661.  
  • Bachelet I, Munitz A, Moretta A, et al. (2006). "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.". J. Immunol. 175 (12): 7989–95. PMID 16339535.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Clark GJ, Green BJ, Hart DN (2000). "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17.". Tissue Antigens 55 (2): 101–9. doi:10.1034/j.1399-0039.2000.550201.x. PMID 10746781.  
  • Cantoni C, Bottino C, Augugliaro R, et al. (1999). "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.". Eur. J. Immunol. 29 (10): 3148–59. doi:10.1002/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L. PMID 10540326.  
  • Green BJ, Clark GJ, Hart DN (1998). "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.". Int. Immunol. 10 (7): 891–9. doi:10.1093/intimm/10.7.891. PMID 9701027.  
  • Jackson DG, Hart DN, Starling G, Bell JI (1992). "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor.". Eur. J. Immunol. 22 (5): 1157–63. doi:10.1002/eji.1830220508. PMID 1349532.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address