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Fc fragment of IgG, low affinity IIa, receptor (CD32)
Symbol FCGR2A
Alt. symbols FCG2, FCGR2A1, FCGR2
Entrez 2212
HUGO 3616
OMIM 146790
RefSeq NM_021642
UniProt P12318
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Symbol FCGR2B
Alt. symbols FCG2, FCGR2
Entrez 2213
HUGO 3618
OMIM 604590
RefSeq NM_004001
UniProt P31994
Other data
Locus Chr. 1 q23
Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Symbol FCGR2C
Entrez 9103
HUGO 15626
RefSeq NM_201563
UniProt P31995
Other data
Locus Chr. 1 q23

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signalling.

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body.[1]

Monoclonal antibodies can distinguish between type A and type B.[2]

External links


  1. ^ Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.
  2. ^ Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMID 17386079.  

Strategy wiki

Up to date as of January 23, 2010
(Redirected to Category:Commodore Amiga CD32 article)

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This system category is a stub. Help us expand it with system details as well as a {{system}} infobox. Reliable information can be researched on Wikipedia or you can just search for "Commodore Amiga CD32" on Google. Do this and you get a cookie.

Commodore Amiga CD32
The console image for Commodore Amiga CD32.
Manufacturer Commodore
Active 19931994
Total Games unknown (10 present)
← Commodore Amiga (none) →
Popular guides
  1. The Lost Vikings

Pages in category "Commodore Amiga CD32"

The following 10 pages are in this category, out of 10 total.



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