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CD33 molecule
Identifiers
Symbol CD33
Alt. symbols SIGLEC3, SIGLEC-3, gp67
Entrez 945
HUGO 1659
OMIM 159590
RefSeq NM_023068
UniProt P20138
Other data
Locus Chr. 19 q13.3

CD33 is a transmembrane receptor expressed on cells of myeloid lineage.[1] It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.[2]

It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

Structure

The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity.[3]

Clinical significance

CD33 is the target of gemtuzumab ozogamicin,[4] a monoclonal antibody-based treated for acute myeloid leukemia.

References

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