The Full Wiki

More info on CD3D

CD3D: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
CD3d molecule, delta (CD3-TCR complex)

PDB rendering based on 1xiw.
Available structures
1xiw
Identifiers
Symbols CD3D; CD3-DELTA; T3D
External IDs OMIM186790 MGI88331 HomoloGene585 GeneCards: CD3D Gene
RNA expression pattern
PBB GE CD3D 213539 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 915 12500
Ensembl ENSG00000167286 ENSMUSG00000032094
UniProt P04234 A0N8K9
RefSeq (mRNA) NM_000732 NM_013487
RefSeq (protein) NP_000723 NP_038515
Location (UCSC) Chr 11:
117.72 - 117.72 Mb
Chr 9:
44.73 - 44.74 Mb
PubMed search [1] [2]

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.[1]

Contents

Interactions

CD3D has been shown to interact with CD8A.[2]

See also

References

  1. ^ "Entrez Gene: CD3D CD3d molecule, delta (CD3-TCR complex)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=915.  
  2. ^ Doucey, Marie-Agnès; Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan. 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. (United States) 278 (5): 3257–64. doi:10.1074/jbc.M208119200. ISSN 0021-9258. PMID 12215456.  

Further reading

  • Balk SP, Polischuk JE, Probert C, et al. (1996). "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain.". Int. Immunol. 7 (8): 1237–41. doi:10.1093/intimm/7.8.1237. PMID 7495730.  
  • Li CJ (2007). "Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference.". J. Cell. Physiol. 209 (3): 695–700. doi:10.1002/jcp.20817. PMID 17001685.  
  • Phillips JH, Hori T, Nagler A, et al. (1992). "Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.". J. Exp. Med. 175 (4): 1055–66. doi:10.1084/jem.175.4.1055. PMID 1372642.  
  • Luzzati AL, Giacomini E, Giordani L, et al. (1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope.". Immunol. Lett. 33 (3): 307–14. doi:10.1016/0165-2478(92)90078-3. PMID 1385321.  
  • Alarcón B, Ley SC, Sánchez-Madrid F, et al. (1991). "The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.". Embo J. 10 (4): 903–12. PMID 1826255.  
  • Hori T, de Waal Malefyt R, Duncan BW, et al. (1991). "Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3.". Int. Immunol. 3 (4): 353–7. doi:10.1093/intimm/3.4.353. PMID 1831653.  
  • Ruegg CL, Strand M (1991). "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.". Cell. Immunol. 137 (1): 1–13. doi:10.1016/0008-8749(91)90051-C. PMID 1832084.  
  • Cefai D, Debre P, Kaczorek M, et al. (1991). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.". J. Clin. Invest. 86 (6): 2117–24. doi:10.1172/JCI114950. PMID 1979339.  
  • Luzzati AL, Pugliese O, Giacomini E, et al. (1990). "Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.". Folia Biol. (Praha) 36 (1): 71–7. PMID 2111780.  
  • Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex.". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083.  
  • Alexander D, Goris J, Marais R, et al. (1989). "Dephosphorylation of the human T lymphocyte CD3 antigen.". Eur. J. Biochem. 181 (1): 55–65. doi:10.1111/j.1432-1033.1989.tb14693.x. PMID 2540970.  
  • Tunnacliffe A, Buluwela L, Rabbitts TH (1988). "Physical linkage of three CD3 genes on human chromosome 11.". Embo J. 6 (10): 2953–7. PMID 2826124.  
  • van den Elsen P, Shepley BA, Cho M, Terhorst C (1985). "Isolation and characterization of a cDNA clone encoding the murine homologue of the human 20K T3/T-cell receptor glycoprotein.". Nature 314 (6011): 542–4. doi:10.1038/314542a0. PMID 2859526.  
  • van den Elsen P, Georgopoulos K, Shepley BA, et al. (1986). "Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.". Proc. Natl. Acad. Sci. U.S.A. 83 (9): 2944–8. doi:10.1073/pnas.83.9.2944. PMID 2939461.  
  • Gold DP, Clevers H, Alarcon B, et al. (1987). "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family.". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7649–53. doi:10.1073/pnas.84.21.7649. PMID 3478717.  
  • Tunnacliffe A, Sims JE, Rabbitts TH (1986). "T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.". Embo J. 5 (6): 1245–52. PMID 3488209.  
  • van den Elsen P, Shepley BA, Borst J, et al. (1985). "Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.". Nature 312 (5993): 413–8. doi:10.1038/312413a0. PMID 6095101.  
  • Oravecz T, Norcross MA (1994). "Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120.". AIDS Res. Hum. Retroviruses 9 (10): 945–55. PMID 7506554.  
  • Luzzati AL, Giacomini E, Giordani L, et al. (1994). "An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex.". Cell. Immunol. 156 (2): 286–95. doi:10.1006/cimm.1994.1175. PMID 7517794.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message