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CD46 molecule, complement regulatory protein

PDB rendering based on 1ckl.
Available structures
1ckl, 2o39
Identifiers
Symbols CD46; MCP; MGC26544; MIC10; TLX; TRA2.10
External IDs OMIM120920 MGI1203290 HomoloGene7832 GeneCards: CD46 Gene
RNA expression pattern
PBB GE CD46 208783 s at tn.png
PBB GE CD46 207549 x at tn.png
PBB GE CD46 211574 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4179 17221
Ensembl ENSG00000117335 ENSMUSG00000016493
UniProt P15529 O88174
RefSeq (mRNA) NM_002389 NM_010778
RefSeq (protein) NP_002380 NP_034908
Location (UCSC) Chr 1:
205.99 - 206.04 Mb
Chr 1:
196.76 - 196.79 Mb
PubMed search [1] [2]

CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) is a protein which in humans is encoded by the CD46 gene.[1] CD46 is an inhibitory complement receptor.[2]

Contents

Gene

This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.[3]

Function

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system.

The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement.[4]

The protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization.[5]

Clinical signficance

The encoded protein can act as a receptor for the Edmonston strain of measles virus,[6] human herpesvirus-6, and type IV pili of pathogenic Neisseria.[7]

Interactions

CD46 has been shown to interact with CD9,[8] CD151[8] and CD29.[8]

References

  1. ^ Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod. 9 (5): 907–11. PMID 7929741. http://humrep.oxfordjournals.org/cgi/content/abstract/9/5/907.  
  2. ^ Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster". Annu. Rev. Immunol. 9: 431–55. doi:10.1146/annurev.iy.09.040191.002243. PMID 1910685.  
  3. ^ "Entrez Gene: CD46 CD46 molecule, complement regulatory protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4179.  
  4. ^ Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP (September 2004). "CD46: expanding beyond complement regulation". Trends Immunol. 25 (9): 496–503. doi:10.1016/j.it.2004.07.004. PMID 15324743.  
  5. ^ Liszewski MK, Kemper C, Price JD, Atkinson JP (November 2005). "Emerging roles and new functions of CD46". Springer Semin. Immunopathol. 27 (3): 345–58. doi:10.1007/s00281-005-0002-3. PMID 16200405.  
  6. ^ Dörig RE, Marcil A, Richardson CD (September 1994). "CD46, a primate-specific receptor for measles virus". Trends Microbiol. 2 (9): 312–8. PMID 7529121.  
  7. ^ Cattaneo R (May 2004). "Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet". J. Virol. 78 (9): 4385–8. doi:10.1128/JVI.78.9.4385-4388.2004. PMID 15078919.  
  8. ^ a b c Lozahic, S; Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (Mar. 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. (GERMANY) 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. ISSN 0014-2980. PMID 10741407.  

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