The Full Wiki

CD49c: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Identifiers
Symbols ITGA3; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a
External IDs OMIM605025 MGI96602 HomoloGene21129 GeneCards: ITGA3 Gene
RNA expression pattern
PBB GE ITGA3 201474 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3675 16400
Ensembl ENSG00000005884 ENSMUSG00000001507
UniProt P26006 Q5SWB9
RefSeq (mRNA) NM_002204 NM_013565
RefSeq (protein) NP_002195 NP_038593
Location (UCSC) Chr 17:
45.49 - 45.52 Mb
Chr 11:
94.86 - 94.89 Mb
PubMed search [1] [2]

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.[1][2] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Contents

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').[3]

Interactions

CD49c has been shown to interact with TSPAN4,[4] LGALS8,[5] CD9[6][7] and FHL2.[8]

References

  1. ^ Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol 115 (1): 257–66. PMID 1655803.  
  2. ^ Jones SD, van der Flier A, Sonnenberg A (Sep 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.  
  3. ^ "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3675.  
  4. ^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. ISSN 0021-9258. PMID 9360996.  
  5. ^ Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND) 113 ( Pt 13): 2385–97. ISSN 0021-9533. PMID 10852818.  
  6. ^ Park, K R; Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (Mar. 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. (ENGLAND) 6 (3): 252–7. ISSN 1360-9947. PMID 10694273.  
  7. ^ Hirano, T; Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (Feb. 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. (ENGLAND) 5 (2): 162–7. ISSN 1360-9947. PMID 10065872.  
  8. ^ Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.  

Further reading

External links

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message