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Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Symbols ITGA3; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a
External IDs OMIM605025 MGI96602 HomoloGene21129 GeneCards: ITGA3 Gene
RNA expression pattern
PBB GE ITGA3 201474 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3675 16400
Ensembl ENSG00000005884 ENSMUSG00000001507
UniProt P26006 Q5SWB9
RefSeq (mRNA) NM_002204 NM_013565
RefSeq (protein) NP_002195 NP_038593
Location (UCSC) Chr 17:
45.49 - 45.52 Mb
Chr 11:
94.86 - 94.89 Mb
PubMed search [1] [2]

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.[1][2] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.


Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').[3]


CD49c has been shown to interact with TSPAN4,[4] LGALS8,[5] CD9[6][7] and FHL2.[8]


  1. ^ Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol 115 (1): 257–66. PMID 1655803.  
  2. ^ Jones SD, van der Flier A, Sonnenberg A (Sep 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.  
  3. ^ "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)".  
  4. ^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. ISSN 0021-9258. PMID 9360996.  
  5. ^ Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND) 113 ( Pt 13): 2385–97. ISSN 0021-9533. PMID 10852818.  
  6. ^ Park, K R; Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (Mar. 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. (ENGLAND) 6 (3): 252–7. ISSN 1360-9947. PMID 10694273.  
  7. ^ Hirano, T; Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (Feb. 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. (ENGLAND) 5 (2): 162–7. ISSN 1360-9947. PMID 10065872.  
  8. ^ Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.  

Further reading

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