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From Wikipedia, the free encyclopedia

CD52 molecule
Identifiers
Symbol CD52
Alt. symbols CDW52
Entrez 1043
HUGO 1804
OMIM 114280
RefSeq NM_001803
UniProt P31358
Other data
Locus Chr. 1 p36

CD52 is a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived.

It also is found in monocytes[1] and dendritic cells.[2]

It is a glycosylphosphatidylinositol (GPI)--anchored antigen expressed on the all lymphocytes as well as within the male genital tract.

Clinical significance

It is the protein targeted by alemtuzumab, an antibody used for the treatment of chronic lymphocytic leukemia.

It is associated with certain types of lymphoma.[3]

References

  1. ^ Buggins AG, Mufti GJ, Salisbury J, et al. (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood 100 (5): 1715–20. PMID 12176892. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12176892.  
  2. ^ Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12393688.  
  3. ^ Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA (2007). "Expression of CD52 in peripheral T-cell lymphoma". Haematologica 92 (4): 566–7. doi:10.3324/haematol.10767. PMID 17488672.  

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