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CD5 (protein): Wikis

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CD5 molecule

PDB rendering based on 2ja4.
Available structures
2ja4, 2ott
Identifiers
Symbols CD5; T1; LEU1
External IDs OMIM153340 MGI88340 HomoloGene7260 GeneCards: CD5 Gene
RNA expression pattern
PBB GE CD5 206485 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 921 12507
Ensembl ENSG00000110448 ENSMUSG00000024669
UniProt P06127 Q3UP78
RefSeq (mRNA) NM_014207 NM_007650
RefSeq (protein) NP_055022 NP_031676
Location (UCSC) Chr 11:
60.63 - 60.65 Mb
Chr 19:
10.79 - 10.81 Mb
PubMed search [1] [2]

CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells.[1] B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by a very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed.

In humans, the gene is located on the long arm of chromosome 11. There is no confimed ligand for CD5.

T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.

Mantle cell lymphoma and small lymphocytic lymphoma also have CD5 markers on their surface.

References

Further reading

  • Berland R, Wortis HH (2002). "Origins and functions of B-1 cells with notes on the role of CD5.". Annu. Rev. Immunol. 20: 253–300. doi:10.1146/annurev.immunol.20.100301.064833. PMID 11861604.  
  • Osman N, Ley SC, Crumpton MJ (1992). "Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes.". Eur. J. Immunol. 22 (11): 2995–3000. doi:10.1002/eji.1830221135. PMID 1385158.  
  • Van de Velde H, von Hoegen I, Luo W, et al. (1991). "The B-cell surface protein CD72/Lyb-2 is the ligand for CD5.". Nature 351 (6328): 662–5. doi:10.1038/351662a0. PMID 1711157.  
  • Jones NH, Clabby ML, Dialynas DP, et al. (1986). "Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1.". Nature 323 (6086): 346–9. doi:10.1038/323346a0. PMID 3093892.  
  • Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex.". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031.  
  • Raab M, Yamamoto M, Rudd CE (1994). "The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.". Mol. Cell. Biol. 14 (5): 2862–70. PMID 7513045.  
  • Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755.  
  • Van de Velde H, Thielemans K (1996). "Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes.". Cell. Immunol. 172 (1): 84–91. doi:10.1006/cimm.1996.0218. PMID 8806810.  
  • Dennehy KM, Broszeit R, Garnett D, et al. (1997). "Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5.". Eur. J. Immunol. 27 (3): 679–86. doi:10.1002/eji.1830270316. PMID 9079809.  
  • Gary-Gouy H, Lang V, Sarun S, et al. (1997). "In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes.". J. Immunol. 159 (8): 3739–47. PMID 9378960.  
  • Dennehy KM, Broszeit R, Ferris WF, Beyers AD (1998). "Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5.". Eur. J. Immunol. 28 (5): 1617–25. doi:10.1002/(SICI)1521-4141(199805)28:05<1617::AID-IMMU1617>3.0.CO;2-7. PMID 9603468.  
  • Bauch A, Campbell KS, Reth M (1998). "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta.". Eur. J. Immunol. 28 (7): 2167–77. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886.  
  • Calvo J, Vildà JM, Places L, et al. (1998). "Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein kinase II.". J. Immunol. 161 (11): 6022–9. PMID 9834084.  
  • McAlister MS, Davis B, Pfuhl M, Driscoll PC (1999). "NMR analysis of the N-terminal SRCR domain of human CD5: engineering of a glycoprotein for superior characteristics in NMR experiments.". Protein Eng. 11 (10): 847–53. doi:10.1093/protein/11.10.847. PMID 9862202.  
  • Perez-Villar JJ, Whitney GS, Bowen MA, et al. (1999). "CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1.". Mol. Cell. Biol. 19 (4): 2903–12. PMID 10082557.  
  • Carmo AM, Castro MA, Arosa FA (1999). "CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells.". J. Immunol. 163 (8): 4238–45. PMID 10510361.  
  • Vilà JM, Calvo J, Places L, et al. (2001). "Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling.". J. Immunol. 166 (1): 396–402. PMID 11123317.  
  • Vilà JM, Gimferrer I, Padilla O, et al. (2001). "Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases.". Eur. J. Immunol. 31 (4): 1191–8. doi:10.1002/1521-4141(200104)31:4<1191::AID-IMMU1191>3.0.CO;2-H. PMID 11298344.  
  • Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMID 11390434.  
  • Gary-Gouy H, Harriague J, Dalloul A, et al. (2002). "CD5-negative regulation of B cell receptor signaling pathways originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif.". J. Immunol. 168 (1): 232–9. PMID 11751967.  

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