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CD6 molecule
Symbols CD6; TP120
External IDs OMIM186720 MGI103566 HomoloGene4893 GeneCards: CD6 Gene
Species Human Mouse
Entrez 923 12511
Ensembl ENSG00000013725 ENSMUSG00000024670
UniProt P30203 Q8BGK1
RefSeq (mRNA) NM_006725 NM_001037801
RefSeq (protein) NP_006716 NP_001032890
Location (UCSC) Chr 11:
60.5 - 60.54 Mb
Chr 19:
10.86 - 10.9 Mb
PubMed search [1] [2]

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[1]


See also


Further reading

  • Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins.". J. Exp. Med. 174 (4): 949–52. doi:10.1084/jem.174.4.949. PMID 1919444.  
  • Swack JA, Mier JW, Romain PL, et al. (1991). "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule.". J. Biol. Chem. 266 (11): 7137–43. PMID 2016320.  
  • Tsuge I, Utsumi KR, Ueda R, et al. (1985). "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11.". Somat. Cell Mol. Genet. 11 (3): 217–22. doi:10.1007/BF01534678. PMID 3923629.  
  • Whitney GS, Starling GC, Bowen MA, et al. (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.". J. Biol. Chem. 270 (31): 18187–90. doi:10.1074/jbc.270.31.18187. PMID 7543097.  
  • Robinson WH, Neuman de Vegvar HE, Prohaska SS, et al. (1995). "Human CD6 possesses a large, alternatively spliced cytoplasmic domain.". Eur. J. Immunol. 25 (10): 2765–9. doi:10.1002/eji.1830251008. PMID 7589069.  
  • Wee S, Schieven GL, Kirihara JM, et al. (1993). "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors.". J. Exp. Med. 177 (1): 219–23. doi:10.1084/jem.177.1.219. PMID 7678115.  
  • Bowen MA, Whitney GS, Neubauer M, et al. (1997). "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.". J. Immunol. 158 (3): 1149–56. PMID 9013954.  
  • Kobarg J, Whitney GS, Palmer D, et al. (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains.". Eur. J. Immunol. 27 (11): 2971–80. doi:10.1002/eji.1830271133. PMID 9394826.  
  • Singer NG, Mitra R, Lialios F, et al. (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes.". Immunol. Lett. 58 (1): 9–14. doi:10.1016/S0165-2478(97)02707-7. PMID 9436462.  
  • Gimferrer I, Farnós M, Calvo M, et al. (2003). "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells.". J. Biol. Chem. 278 (10): 8564–71. doi:10.1074/jbc.M209591200. PMID 12473675.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.  
  • Gimferrer I, Ibáñez A, Farnós M, et al. (2005). "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains.". J. Immunol. 175 (3): 1406–14. PMID 16034076.  
  • Kato Y, Tanaka Y, Hayashi M, et al. (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens.". J. Immunol. 177 (2): 877–84. PMID 16818742.  
  • Ibáñez A, Sarrias MR, Farnós M, et al. (2006). "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor.". J. Immunol. 177 (2): 1152–9. PMID 16818773.  
  • Hassan NJ, Simmonds SJ, Clarkson NG, et al. (2006). "CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.". Mol. Cell. Biol. 26 (17): 6727–38. doi:10.1128/MCB.00688-06. PMID 16914752.  
  • Castro MA, Oliveira MI, Nunes RJ, et al. (2007). "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse.". J. Immunol. 178 (7): 4351–61. PMID 17371992.  
  • Sarrias MR, Farnós M, Mota R, et al. (2007). "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock.". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11724–9. doi:10.1073/pnas.0702815104. PMID 17601777.  

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