The Full Wiki

CD61: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

PDB rendering based on 1jv2.
Available structures
1jv2, 1l5g, 1m1x, 1m8o, 1txv, 1ty3, 1ty5, 1ty6, 1ty7, 1tye, 1u8c
Symbols ITGB3; CD61; GP3A; GPIIIa
External IDs OMIM173470 MGI96612 HomoloGene55444 GeneCards: ITGB3 Gene
RNA expression pattern
PBB GE ITGB3 204628 s at tn.png
PBB GE ITGB3 204625 s at tn.png
PBB GE ITGB3 204626 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3690 16416
Ensembl ENSG00000056345 ENSMUSG00000020689
UniProt P05106 P97483
RefSeq (mRNA) NM_000212 NM_016780
RefSeq (protein) NP_000203 NP_058060
Location (UCSC) Chr 17:
42.69 - 42.75 Mb
Chr 11:
104.42 - 104.48 Mb
PubMed search [1] [2]

Integrin beta-3 is a protein that in humans is encoded by the ITGB3 gene.[1] CD61 is a cluster of differentiation found on thrombocytes.

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.[2]



CD61 has been shown to interact with PTK2,[3][4] ITGB3BP,[5][6] TLN1[7][8] and CIB1.[9]

See also


  1. ^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMID 2454952.  
  2. ^ "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".  
  3. ^ Eliceiri, Brian P; Puente Xose S, Hood John D, Stupack Dwayne G, Schlaepfer David D, Huang Xiaozhu Z, Sheppard Dean, Cheresh David A (Apr. 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. (United States) 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMID 11927607.  
  4. ^ Chung, J; Gao A G, Frazier W A (Jun. 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. (UNITED STATES) 272 (23): 14740–6. ISSN 0021-9258. PMID 9169439.  
  5. ^ Fujimoto, Tetsuro-Takahiro; Katsutani Shinya, Shimomura Takeshi, Fujimura Kingo (Jan. 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. (United States) 105 (1): 63–70. ISSN 0049-3848. PMID 11864709.  
  6. ^ Shattil, S J; O'Toole T, Eigenthaler M, Thon V, Williams M, Babior B M, Ginsberg M H (Nov. 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J. Cell Biol. (UNITED STATES) 131 (3): 807–16. ISSN 0021-9525. PMID 7593198.  
  7. ^ Patil, S; Jedsadayanmata A, Wencel-Drake J D, Wang W, Knezevic I, Lam S C (Oct. 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. (UNITED STATES) 274 (40): 28575–83. ISSN 0021-9258. PMID 10497223.  
  8. ^ Calderwood, David A; Yan Boxu, de Pereda Jose M, Alvarez Begoña García, Fujioka Yosuke, Liddington Robert C, Ginsberg Mark H (Jun. 2002). "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. (United States) 277 (24): 21749–58. doi:10.1074/jbc.M111996200. ISSN 0021-9258. PMID 11932255.  
  9. ^ Naik, U P; Patel P M, Parise L V (Feb. 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J. Biol. Chem. (UNITED STATES) 272 (8): 4651–4. ISSN 0021-9258. PMID 9030514.  

Further reading

  • Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.  
  • Bennett JS (2001). "Platelet-fibrinogen interactions.". Ann. N. Y. Acad. Sci. 936: 340–54. PMID 11460491.  
  • Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187–93. PMID 11858476.  
  • Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.  
  • Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.". Italian heart journal : official journal of the Italian Federation of Cardiology 4 (1): 17–22. PMID 12690916.  
  • Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.". Thromb. Res. 112 (4): 209–16. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.  
  • Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.". Curr. Pharm. Des. 10 (14): 1567–76. doi:10.2174/1381612043384682. PMID 15134555.  
  • Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51–70. PMID 15638730.  
  • Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.  
  • Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3.". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMID 16322781.  

External links



Got something to say? Make a comment.
Your name
Your email address