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CD79a molecule, immunoglobulin-associated alpha
Symbols CD79A; IGA; MB-1
External IDs OMIM112205 MGI101774 HomoloGene31053 GeneCards: CD79A Gene
RNA expression pattern
PBB GE CD79A 205049 s at tn.png
More reference expression data
Species Human Mouse
Entrez 973 12518
Ensembl ENSG00000105369 n/a
UniProt P11912 n/a
RefSeq (mRNA) NM_001783 XM_989437
RefSeq (protein) NP_001774 XP_994531
Location (UCSC) Chr 19:
47.07 - 47.08 Mb
PubMed search [1] [2]

CD79a molecule, immunoglobulin-associated alpha, also known as CD79A (Cluster of Differentiation 79A), is a human gene.[1]

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[1]



CD79A has been shown to interact with B-cell linker[2][3] and Alpha-1-microglobulin/bikunin precursor.[4][5]

See also


  1. ^ a b "Entrez Gene: CD79A CD79a molecule, immunoglobulin-associated alpha".  
  2. ^ Engels, N; Wollscheid B, Wienands J (Jul. 2001). "Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha". Eur. J. Immunol. (Germany) 31 (7): 2126–34. ISSN 0014-2980. PMID 11449366.  
  3. ^ Kabak, Shara; Skaggs Brian J, Gold Michael R, Affolter Michael, West Kelly L, Foster Mark S, Siemasko Karyn, Chan Andrew C, Aebersold Ruedi, Clark Marcus R (Apr. 2002). "The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways". Mol. Cell. Biol. (United States) 22 (8): 2524–35. ISSN 0270-7306. PMID 11909947.  
  4. ^ Grubb, A O; López C, Tejler L, Mendez E (Dec. 1983). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration". J. Biol. Chem. (UNITED STATES) 258 (23): 14698–707. ISSN 0021-9258. PMID 6196366.  
  5. ^ Berggård, T; Thelin N, Falkenberg C, Enghild J J, Akerström B (May. 1997). "Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma". Eur. J. Biochem. (GERMANY) 245 (3): 676–83. ISSN 0014-2956. PMID 9183005.  

Further reading

  • Reth M (1992). "Antigen receptors on B lymphocytes.". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.  
  • Herren B, Burrows PD (2003). "B cell-restricted human mb-1 gene: expression, function, and lineage infidelity.". Immunol. Res. 26 (1-3): 35–43. doi:10.1385/IR:26:1-3:035. PMID 12403343.  
  • Bastian A, Kratzin H, Eckart K, Hilschmann N (1993). "Intra- and interchain disulfide bridges of the human J chain in secretory immunoglobulin A.". Biol. Chem. Hoppe-Seyler 373 (12): 1255–63. PMID 1292512.  
  • Leduc I, Preud'homme JL, Cogné M (1992). "Structure and expression of the mb-1 transcript in human lymphoid cells.". Clin. Exp. Immunol. 90 (1): 141–6. PMID 1395095.  
  • Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing error frequency in the DNA sequence databases.". DNA Seq. 2 (6): 343–6. doi:10.3109/10425179209020815. PMID 1446073.  
  • Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761.  
  • Ha HJ, Kubagawa H, Burrows PD (1992). "Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.". J. Immunol. 148 (5): 1526–31. PMID 1538135.  
  • Hutchcroft JE, Harrison ML, Geahlen RL (1992). "Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.". J. Biol. Chem. 267 (12): 8613–9. PMID 1569106.  
  • Flaswinkel H, Reth M (1992). "Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex.". Immunogenetics 36 (4): 266–9. doi:10.1007/BF00215058. PMID 1639443.  
  • Yu LM, Chang TW (1992). "Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes.". J. Immunol. 148 (2): 633–7. PMID 1729378.  
  • Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (1991). "The B-cell antigen receptor of the five immunoglobulin classes.". Nature 352 (6338): 777–81. doi:10.1038/352777a0. PMID 1881434.  
  • Bakos MA, Kurosky A, Goldblum RM (1991). "Characterization of a critical binding site for human polymeric Ig on secretory component.". J. Immunol. 147 (10): 3419–26. PMID 1940346.  
  • Sakaguchi N, Kashiwamura S, Kimoto M, et al. (1989). "B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties.". EMBO J. 7 (11): 3457–64. PMID 2463161.  
  • Grubb AO, López C, Tejler L, Mendez E (1984). "Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration.". J. Biol. Chem. 258 (23): 14698–707. PMID 6196366.  
  • Kurosaki T, Johnson SA, Pao L, et al. (1996). "Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling.". J. Exp. Med. 182 (6): 1815–23. doi:10.1084/jem.182.6.1815. PMID 7500027.  
  • Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex.". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031.  
  • Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.  
  • Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.". J. Biol. Chem. 269 (25): 17238–44. PMID 7516335.  
  • Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMID 7539038.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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