The Full Wiki

More info on CD79B

CD79B: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
CD79b molecule, immunoglobulin-associated beta
Identifiers
Symbols CD79B; B29; IGB
External IDs OMIM147245 MGI96431 HomoloGene521 GeneCards: CD79B Gene
RNA expression pattern
PBB GE CD79B 205297 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 974 15985
Ensembl ENSG00000007312 ENSMUSG00000040592
UniProt P40259 Q4FJP4
RefSeq (mRNA) NM_000626 NM_008339
RefSeq (protein) NP_000617 NP_032365
Location (UCSC) Chr 17:
59.36 - 59.36 Mb
Chr 11:
106.13 - 106.13 Mb
PubMed search [1] [2]

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.[1]

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

Contents

See also

References

Further reading

  • Reth M (1992). "Antigen receptors on B lymphocytes.". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.  
  • Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761.  
  • Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex.". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031.  
  • Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.  
  • Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.". J. Biol. Chem. 269 (25): 17238–44. PMID 7516335.  
  • Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.". J. Biol. Chem. 270 (19): 11590–4. doi:10.1074/jbc.270.19.11590. PMID 7538118.  
  • Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMID 7539038.  
  • Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29).". Immunol. Lett. 44 (2-3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.  
  • Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells.". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.  
  • Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.". Mol. Immunol. 32 (9): 651–9. doi:10.1016/0161-5890(95)00023-8. PMID 7643857.  
  • Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.". Immunogenetics 40 (2): 145–9. doi:10.1007/BF00188178. PMID 7913081.  
  • Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.". J. Immunol. 153 (6): 2369–80. PMID 8077654.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.". J. Immunol. 150 (2): 491–8. PMID 8419481.  
  • Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).". Genomics 16 (1): 187–92. doi:10.1006/geno.1993.1157. PMID 8486355.  
  • Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5' flanking sequences controlling human B29 gene expression.". Blood 87 (2): 666–73. PMID 8555489.  
  • Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia.". Leukemia 10 (5): 769–73. PMID 8656670.  
  • Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing.". Immunol. Lett. 47 (3): 151–6. doi:10.1016/0165-2478(95)00071-X. PMID 8747711.  
  • Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex.". J. Immunol. 158 (7): 3062–9. PMID 9120258.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message