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CD79b molecule, immunoglobulin-associated beta
Symbols CD79B; B29; IGB
External IDs OMIM147245 MGI96431 HomoloGene521 GeneCards: CD79B Gene
RNA expression pattern
PBB GE CD79B 205297 s at tn.png
More reference expression data
Species Human Mouse
Entrez 974 15985
Ensembl ENSG00000007312 ENSMUSG00000040592
UniProt P40259 Q4FJP4
RefSeq (mRNA) NM_000626 NM_008339
RefSeq (protein) NP_000617 NP_032365
Location (UCSC) Chr 17:
59.36 - 59.36 Mb
Chr 11:
106.13 - 106.13 Mb
PubMed search [1] [2]

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene.[1]

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.[1]


See also


Further reading

  • Reth M (1992). "Antigen receptors on B lymphocytes.". Annu. Rev. Immunol. 10: 97–121. doi:10.1146/annurev.iy.10.040192.000525. PMID 1591006.  
  • Müller B, Cooper L, Terhorst C (1992). "Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29.". Eur. J. Immunol. 22 (6): 1621–5. doi:10.1002/eji.1830220641. PMID 1534761.  
  • Lankester AC, van Schijndel GM, Cordell JL, et al. (1994). "CD5 is associated with the human B cell antigen receptor complex.". Eur. J. Immunol. 24 (4): 812–6. doi:10.1002/eji.1830240406. PMID 7512031.  
  • Vasile S, Coligan JE, Yoshida M, Seon BK (1994). "Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex.". Mol. Immunol. 31 (6): 419–27. doi:10.1016/0161-5890(94)90061-2. PMID 7514267.  
  • Brown VK, Ogle EW, Burkhardt AL, et al. (1994). "Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45.". J. Biol. Chem. 269 (25): 17238–44. PMID 7516335.  
  • Rowley RB, Burkhardt AL, Chao HG, et al. (1995). "Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.". J. Biol. Chem. 270 (19): 11590–4. doi:10.1074/jbc.270.19.11590. PMID 7538118.  
  • Pani G, Kozlowski M, Cambier JC, et al. (1995). "Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.". J. Exp. Med. 181 (6): 2077–84. doi:10.1084/jem.181.6.2077. PMID 7539038.  
  • Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29).". Immunol. Lett. 44 (2-3): 97–103. doi:10.1016/0165-2478(94)00199-2. PMID 7541024.  
  • Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells.". J. Biol. Chem. 270 (45): 27072–8. doi:10.1074/jbc.270.45.27072. PMID 7592958.  
  • Hashimoto S, Chiorazzi N, Gregersen PK (1995). "Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells.". Mol. Immunol. 32 (9): 651–9. doi:10.1016/0161-5890(95)00023-8. PMID 7643857.  
  • Hashimoto S, Chiorazzi N, Gregersen PK (1994). "The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.". Immunogenetics 40 (2): 145–9. doi:10.1007/BF00188178. PMID 7913081.  
  • Gold MR, Chiu R, Ingham RJ, et al. (1994). "Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes.". J. Immunol. 153 (6): 2369–80. PMID 8077654.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Hashimoto S, Gregersen PK, Chiorazzi N (1993). "The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes.". J. Immunol. 150 (2): 491–8. PMID 8419481.  
  • Wood WJ, Thompson AA, Korenberg J, et al. (1993). "Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).". Genomics 16 (1): 187–92. doi:10.1006/geno.1993.1157. PMID 8486355.  
  • Thompson AA, Wood WJ, Gilly MJ, et al. (1996). "The promoter and 5' flanking sequences controlling human B29 gene expression.". Blood 87 (2): 666–73. PMID 8555489.  
  • Astsaturov IA, Matutes E, Morilla R, et al. (1996). "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia.". Leukemia 10 (5): 769–73. PMID 8656670.  
  • Koyama M, Nakamura T, Higashihara M, et al. (1996). "The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing.". Immunol. Lett. 47 (3): 151–6. doi:10.1016/0165-2478(95)00071-X. PMID 8747711.  
  • Carter RH, Doody GM, Bolen JB, Fearon DT (1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex.". J. Immunol. 158 (7): 3062–9. PMID 9120258.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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