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CD8a molecule

PDB rendering based on 1akj.
Available structures
1akj, 1cd8, 2hp4
Symbols CD8A; p32; CD8; Leu2; MAL
External IDs OMIM186910 MGI88346 HomoloGene1339 GeneCards: CD8A Gene
RNA expression pattern
PBB GE CD8A 205758 at tn.png
More reference expression data
Species Human Mouse
Entrez 925 12525
Ensembl ENSG00000153563 n/a
UniProt P01732 n/a
RefSeq (mRNA) NM_001768 XM_132621
RefSeq (protein) NP_001759 XP_132621
Location (UCSC) Chr 2:
86.87 - 86.87 Mb
PubMed search [1] [2]

CD8a (Cluster of Differentiation 8a), is a human gene.[1]

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.[1]



CD8A has been shown to interact with CD3D,[2] HLA-G[3][4] and HLA-A.[5][3]

See also


  1. ^ a b "Entrez Gene: CD8A CD8a molecule".  
  2. ^ Doucey, Marie-Agnès; Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F (Jan. 2003). "CD3 delta establishes a functional link between the T cell receptor and CD8". J. Biol. Chem. (United States) 278 (5): 3257–64. doi:10.1074/jbc.M208119200. ISSN 0021-9258. PMID 12215456.  
  3. ^ a b Gao, G F; Willcox B E, Wyer J R, Boulter J M, O'Callaghan C A, Maenaka K, Stuart D I, Jones E Y, Van Der Merwe P A, Bell J I, Jakobsen B K (May. 2000). "Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha". J. Biol. Chem. (UNITED STATES) 275 (20): 15232–8. ISSN 0021-9258. PMID 10809759.  
  4. ^ Sanders, S K; Giblin P A, Kavathas P (Sep. 1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts". J. Exp. Med. (UNITED STATES) 174 (3): 737–40. ISSN 0022-1007. PMID 1908512.  
  5. ^ Gao, G F; Tormo J, Gerth U C, Wyer J R, McMichael A J, Stuart D I, Bell J I, Jones E Y, Jakobsen B K (Jun. 1997). "Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2". Nature (ENGLAND) 387 (6633): 630–4. doi:10.1038/42523. ISSN 0028-0836. PMID 9177355.  

Further reading

  • Parnes JR (1989). "Molecular biology and function of CD4 and CD8.". Adv. Immunol. 44: 265–311. doi:10.1016/S0065-2776(08)60644-6. PMID 2493728.  
  • Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.". Cell Res. 15 (11-12): 923–34. doi:10.1038/ PMID 16354571.  
  • Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.  
  • Nakayama K, Kawachi Y, Tokito S, et al. (1992). "Recent duplication of the two human CD8 beta-chain genes.". J. Immunol. 148 (6): 1919–27. PMID 1541829.  
  • Leahy DJ, Axel R, Hendrickson WA (1992). "Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution.". Cell 68 (6): 1145–62. doi:10.1016/0092-8674(92)90085-Q. PMID 1547508.  
  • Erickson JD, Trojanowski JQ, Eiden LE (1991). "Regional distribution and partial molecular characterization of CD4-related mRNA in human brain and peripheral tissues.". Brain Res. Mol. Brain Res. 10 (1): 23–31. doi:10.1016/0169-328X(91)90052-Y. PMID 1676132.  
  • Moebius U, Kober G, Griscelli AL, et al. (1991). "Expression of different CD8 isoforms on distinct human lymphocyte subpopulations.". Eur. J. Immunol. 21 (8): 1793–800. doi:10.1002/eji.1830210803. PMID 1831127.  
  • Mittler RS, Rankin BM, Kiener PA (1991). "Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells.". J. Immunol. 147 (10): 3434–40. PMID 1834739.  
  • Sanders SK, Giblin PA, Kavathas P (1991). "Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts.". J. Exp. Med. 174 (3): 737–40. doi:10.1084/jem.174.3.737. PMID 1908512.  
  • Barber EK, Dasgupta JD, Schlossman SF, et al. (1989). "The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3277–81. doi:10.1073/pnas.86.9.3277. PMID 2470098.  
  • Norment AM, Lonberg N, Lacy E, Littman DR (1989). "Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene.". J. Immunol. 142 (9): 3312–9. PMID 2496167.  
  • Nakayama K, Tokito S, Okumura K, Nakauchi H (1989). "Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8).". Immunogenetics 30 (5): 393–7. doi:10.1007/BF02425282. PMID 2509342.  
  • Giblin P, Ledbetter JA, Kavathas P (1989). "A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 998–1002. doi:10.1073/pnas.86.3.998. PMID 2536941.  
  • Aruffo A, Seed B (1989). "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.". J. Immunol. 143 (5): 1723–30. PMID 2701945.  
  • Bowcock AM, Kavathas P, Margolskee RF, et al. (1986). "An RFLP associated with pcDLeu2-14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12.". Nucleic Acids Res. 14 (19): 7817. doi:10.1093/nar/14.19.7817. PMID 2877435.  
  • Norment AM, Littman DR (1989). "A second subunit of CD8 is expressed in human T cells.". Embo J. 7 (11): 3433–9. PMID 3145195.  
  • Littman DR, Thomas Y, Maddon PJ, et al. (1985). "The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.". Cell 40 (2): 237–46. doi:10.1016/0092-8674(85)90138-2. PMID 3871356.  
  • Sukhatme VP, Sizer KC, Vollmer AC, et al. (1985). "The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.". Cell 40 (3): 591–7. doi:10.1016/0092-8674(85)90207-7. PMID 3918796.  
  • Parnes JR, Sizer KC, Sukhatme VP, Hunkapiller T (1986). "Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone.". Behring Inst. Mitt. (77): 48–55. PMID 3936473.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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