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CD93 molecule
Identifiers
Symbols CD93; C1QR1; C1qR(P); C1qRP; CDw93; MXRA4; dJ737E23.1
External IDs OMIM120577 MGI106664 HomoloGene7823 GeneCards: CD93 Gene
RNA expression pattern
PBB GE CD93 202878 s at tn.png
PBB GE CD93 202877 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22918 17064
Ensembl ENSG00000125810 ENSMUSG00000027435
UniProt Q9NPY3 O89103
RefSeq (mRNA) NM_012072 XM_993058
RefSeq (protein) NP_036204 XP_998152
Location (UCSC) Chr 20:
23.01 - 23.01 Mb
Chr 2:
148.13 - 148.13 Mb
PubMed search [1] [2]

CD93 (Cluster of Differentiation 93) is a human protein encoded by the CD93 gene.[1]

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.[1]

Contents

See also

References

Further reading

  • Tenner AJ (1999). "C1q receptors: regulating specific functions of phagocytic cells.". Immunobiology 199 (2): 250–64. PMID 9777410.  
  • Ghebrehiwet B, Peerschke EI, Hong Y, et al. (1992). "Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV.". J. Leukoc. Biol. 51 (6): 546–56. PMID 1377218.  
  • Peerschke EI, Ghebrehiwet B (1990). "Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.". J. Immunol. 145 (9): 2984–8. PMID 2212670.  
  • Eggleton P, Lieu TS, Zappi EG, et al. (1994). "Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein.". Clin. Immunol. Immunopathol. 72 (3): 405–9. doi:10.1006/clin.1994.1160. PMID 8062452.  
  • Joseph K, Ghebrehiwet B, Peerschke EI, et al. (1996). "Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R).". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8552–7. doi:10.1073/pnas.93.16.8552. PMID 8710908.  
  • Nepomuceno RR, Henschen-Edman AH, Burgess WH, Tenner AJ (1997). "cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro.". Immunity 6 (2): 119–29. doi:10.1016/S1074-7613(00)80419-7. PMID 9047234.  
  • Cáceres J, Brandan E (1997). "Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.". J. Cell. Biochem. 65 (2): 145–58. doi:10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U. PMID 9136074.  
  • Nepomuceno RR, Tenner AJ (1998). "C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets.". J. Immunol. 160 (4): 1929–35. PMID 9469455.  
  • Stuart GR, Lynch NJ, Day AJ, et al. (1998). "The C1q and collectin binding site within C1q receptor (cell surface calreticulin).". Immunopharmacology 38 (1-2): 73–80. doi:10.1016/S0162-3109(97)00076-3. PMID 9476117.  
  • Nepomuceno RR, Ruiz S, Park M, Tenner AJ (1999). "C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity.". J. Immunol. 162 (6): 3583–9. PMID 10092817.  
  • Norsworthy PJ, Taylor PR, Walport MJ, Botto M (1999). "Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p).". Mamm. Genome 10 (8): 789–93. doi:10.1007/s003359901093. PMID 10430665.  
  • Webster SD, Park M, Fonseca MI, Tenner AJ (2000). "Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis.". J. Leukoc. Biol. 67 (1): 109–16. PMID 10648005.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Kittlesen DJ, Chianese-Bullock KA, Yao ZQ, et al. (2001). "Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation.". J. Clin. Invest. 106 (10): 1239–49. doi:10.1172/JCI10323. PMID 11086025.  
  • Joseph K, Shibayama Y, Ghebrehiwet B, Kaplan AP (2001). "Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1.". Thromb. Haemost. 85 (1): 119–24. PMID 11204562.  
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Steinberger P, Szekeres A, Wille S, et al. (2002). "Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning.". J. Leukoc. Biol. 71 (1): 133–40. PMID 11781389.  
  • McGreal EP, Ikewaki N, Akatsu H, et al. (2002). "Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.". J. Immunol. 168 (10): 5222–32. PMID 11994479.  

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