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CD97 molecule

PDB rendering based on 2bo2.
Available structures
2bo2, 2bou, 2box
Symbols CD97; TM7LN1
External IDs OMIM601211 MGI1347095 HomoloGene8050 IUPHAR: CD97 GeneCards: CD97 Gene
RNA expression pattern
PBB GE CD97 202910 s at tn.png
More reference expression data
Species Human Mouse
Entrez 976 26364
Ensembl ENSG00000123146 ENSMUSG00000002885
UniProt P48960 Q9Z0M6
RefSeq (mRNA) NM_001025160 NM_011925
RefSeq (protein) NP_001020331 NP_036055
Location (UCSC) Chr 19:
14.35 - 14.38 Mb
Chr 8:
86.61 - 86.63 Mb
PubMed search [1] [2]

CD97 antigen is a protein that in humans is encoded by the CD97 gene.[1][2][3]

This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.[3]


  1. ^ Hamann J, Eichler W, Hamann D, Kerstens HM, Poddighe PJ, Hoovers JM, Hartmann E, Strauss M, van Lier RA (Sep 1995). "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain". J Immunol 155 (4): 1942-50. PMID 7636245.  
  2. ^ Hamann J, Hartmann E, van Lier RA (Sep 1996). "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily". Genomics 32 (1): 144-7. doi:10.1006/geno.1996.0092. PMID 8786105.  
  3. ^ a b "Entrez Gene: CD97 CD97 molecule".  

Further reading

  • Mustafa T, Klonisch T, Hombach-Klonisch S, Kehlen A, Schmutzler C, Koehrle J, Gimm O, Dralle H, Hoang-Vu C (February 2004). "Expression of CD97 and CD55 in human medullary thyroid carcinomas". Int. J. Oncol. 24 (2): 285–94. PMID 14719104.  
  • Mustafa T, Eckert A, Klonisch T, Kehlen A, Maurer P, Klintschar M, Erhuma M, Zschoyan R, Gimm O, Dralle H, Schubert J, Hoang-Vu C (January 2005). "Expression of the epidermal growth factor seven-transmembrane member CD97 correlates with grading and staging in human oral squamous cell carcinomas". Cancer Epidemiol. Biomarkers Prev. 14 (1): 108–19. PMID 15668483.  
  • Kwakkenbos MJ, Kop EN, Stacey M, et al. (2004). "The EGF-TM7 family: a postgenomic view.". Immunogenetics 55 (10): 655–66. doi:10.1007/s00251-003-0625-2. PMID 14647991.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Gray JX, Haino M, Roth MJ, et al. (1997). "CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation.". J. Immunol. 157 (12): 5438–47. PMID 8955192.  
  • Hamann J, Vogel B, van Schijndel GM, van Lier RA (1997). "The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF).". J. Exp. Med. 184 (3): 1185–9. doi:10.1084/jem.184.3.1185. PMID 9064337.  
  • Aust G, Eichler W, Laue S, et al. (1997). "CD97: a dedifferentiation marker in human thyroid carcinomas.". Cancer Res. 57 (9): 1798–806. PMID 9135025.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Ghannadan M, Baghestanian M, Wimazal F, et al. (1998). "Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies.". J. Invest. Dermatol. 111 (4): 689–95. doi:10.1046/j.1523-1747.1998.00359.x. PMID 9764855.  
  • Qian YM, Haino M, Kelly K, Song WC (1999). "Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55).". Immunology 98 (2): 303–11. doi:10.1046/j.1365-2567.1999.00859.x. PMID 10540231.  
  • Eichler W (2000). "CD97 isoform expression in leukocytes.". J. Leukoc. Biol. 68 (4): 561–7. PMID 11037979.  
  • Lin HH, Stacey M, Saxby C, et al. (2001). "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.". J. Biol. Chem. 276 (26): 24160–9. doi:10.1074/jbc.M101770200. PMID 11297558.  
  • Jaspars LH, Vos W, Aust G, et al. (2001). "Tissue distribution of the human CD97 EGF-TM7 receptor.". Tissue Antigens 57 (4): 325–31. doi:10.1034/j.1399-0039.2001.057004325.x. PMID 11380941.  
  • Steinert M, Wobus M, Boltze C, et al. (2002). "Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues.". Am. J. Pathol. 161 (5): 1657–67. PMID 12414513.  
  • Visser L, de Vos AF, Hamann J, et al. (2003). "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis.". J. Neuroimmunol. 132 (1-2): 156–63. doi:10.1016/S0165-5728(02)00306-5. PMID 12417446.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Stacey M, Chang GW, Davies JQ, et al. (2003). "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.". Blood 102 (8): 2916–24. doi:10.1182/blood-2002-11-3540. PMID 12829604.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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