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solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Identifiers
Symbol SLC3A2
Alt. symbols MDU1, 4T2HC, 4F2, NACAE
Entrez 6520
HUGO 11026
OMIM 158070
RefSeq NM_001013251
UniProt P08195
Other data
Locus Chr. 11 q12-q22
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Identifiers
Symbol SLC7A5
Alt. symbols LAT1, E16, D16S469E, MPE16, CD98
Entrez 8140
HUGO 11063
OMIM 600182
RefSeq NM_003486
UniProt Q01650
Other data
Locus Chr. 16 q24.3

CD98 is a glycoprotein[1][2] that comprises the light subunit of the Large neutral Amino acid Transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.[3] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.[3]

A functional LAT1 transporter is composed of two proteins encoded by two distinct genes:

  • 4F2hc heavy subunit protein encoded by the SLC3A2 gene [4]
  • CD98 light subunit protein encoded by the SLC7A5 gene[5]

See also

References

  1. ^ Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D (2005). "Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation". Lab. Invest. 85 (7): 932–41. doi:10.1038/labinvest.3700289. PMID 15880135.  
  2. ^ Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G (2005). "CD98, a novel marker of transient amplifying human keratinocytes". Proteomics 5 (14): 3637–45. doi:10.1002/pmic.200401224. PMID 16097038.  
  3. ^ a b Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM (1999). "Selective expression of the large neutral amino acid transporter at the blood-brain barrier". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 12079–84. doi:10.1073/pnas.96.21.12079. PMID 10518579.  
  4. ^ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309.  
  5. ^ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310.  

External links

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