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From Wikipedia, the free encyclopedia

CUB domain containing protein 1
Symbols CDCP1; CD318; SIMA135; TRASK
External IDs MGI2442010 HomoloGene11276 GeneCards: CDCP1 Gene
RNA expression pattern
PBB GE CDCP1 218451 at tn.png
More reference expression data
Species Human Mouse
Entrez 64866 109332
Ensembl ENSG00000163814 ENSMUSG00000035498
UniProt Q9H5V8 Q05D42
RefSeq (mRNA) NM_022842 NM_133974
RefSeq (protein) NP_073753 NP_598735
Location (UCSC) Chr 3:
45.1 - 45.16 Mb
Chr 9:
123.02 - 123.06 Mb
PubMed search [1] [2]

CUB domain-containing protein 1 is a protein that in humans is encoded by the CDCP1 gene.[1][2] CDCP1 has also been designated as CD318 (cluster of differentiation 318).

The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]


  1. ^ Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N (Jul 2001). "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer". Oncogene 20 (32): 4402-8. PMID 11466621.  
  2. ^ a b "Entrez Gene: CDCP1 CUB domain containing protein 1".  

Further reading

  • Xia Y, Gil SG, Carter WG (1996). "Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein.". J. Cell Biol. 132 (4): 727–40. doi:10.1083/jcb.132.4.727. PMID 8647901.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Hooper JD, Zijlstra A, Aimes RT, et al. (2003). "Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen.". Oncogene 22 (12): 1783–94. doi:10.1038/sj.onc.1206220. PMID 12660814.  
  • Conze T, Lammers R, Kuci S, et al. (2003). "CDCP1 is a novel marker for hematopoietic stem cells.". Ann. N. Y. Acad. Sci. 996: 222–6. doi:10.1111/j.1749-6632.2003.tb03249.x. PMID 12799299.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Brown TA, Yang TM, Zaitsevskaia T, et al. (2004). "Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia.". J. Biol. Chem. 279 (15): 14772–83. doi:10.1074/jbc.M309678200. PMID 14739293.  
  • Bühring HJ, Kuçi S, Conze T, et al. (2005). "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin.". Stem Cells 22 (3): 334–43. doi:10.1634/stemcells.22-3-334. PMID 15153610.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Benes CH, Wu N, Elia AE, et al. (2005). "The C2 domain of PKCdelta is a phosphotyrosine binding domain.". Cell 121 (2): 271–80. doi:10.1016/j.cell.2005.02.019. PMID 15851033.  
  • Bhatt AS, Erdjument-Bromage H, Tempst P, et al. (2005). "Adhesion signaling by a novel mitotic substrate of src kinases.". Oncogene 24 (34): 5333–43. doi:10.1038/sj.onc.1208582. PMID 16007225.  
  • André M, Le Caer JP, Greco C, et al. (2006). "Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS.". Proteomics 6 (5): 1437–49. doi:10.1002/pmic.200500180. PMID 16404722.  
  • Kimura H, Morii E, Ikeda JI, et al. (2006). "Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells.". Leukemia 20 (9): 1551–6. doi:10.1038/sj.leu.2404312. PMID 16926850.  
  • Perry SE, Robinson P, Melcher A, et al. (2007). "Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells.". FEBS Lett. 581 (6): 1137–42. doi:10.1016/j.febslet.2007.02.025. PMID 17335815.  
  • Uekita T, Jia L, Narisawa-Saito M, et al. (2007). "CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma.". Mol. Cell. Biol. 27 (21): 7649–60. doi:10.1128/MCB.01246-07. PMID 17785447.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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