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Cadherin 11, type 2, OB-cadherin (osteoblast)

PDB rendering based on 2a4c.
Available structures
2a4c, 2a4e
Symbols CDH11; CAD11; CDHOB; OB; OSF-4
External IDs OMIM600023 MGI99217 HomoloGene1361 GeneCards: CDH11 Gene
RNA expression pattern
PBB GE CDH11 207172 s at tn.png
PBB GE CDH11 207173 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1009 12552
Ensembl ENSG00000140937 n/a
UniProt P55287 n/a
RefSeq (mRNA) NM_001797 NM_009866
RefSeq (protein) NP_001788 NP_033996
Location (UCSC) Chr 16:
63.54 - 63.71 Mb
PubMed search [1] [2]

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.[1][2]

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.[2]


CDH11 has been shown to interact with CDH2.[3]


  1. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.  
  2. ^ a b "Entrez Gene: CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)".  
  3. ^ Straub, Beate K; Boda Judit, Kuhn Caecilia, Schnoelzer Martina, Korf Ulrike, Kempf Tore, Spring Herbert, Hatzfeld Mechthild, Franke Werner W (Dec. 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. (England) 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. ISSN 0021-9533. PMID 14625392.  

Further reading

  • Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.". Cell Regul. 2 (4): 261–70. PMID 2059658.  
  • Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID 7982033.  
  • Okazaki M, Takeshita S, Kawai S, et al. (1994). "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.". J. Biol. Chem. 269 (16): 12092–8. PMID 8163513.  
  • Getsios S, Chen GT, Stephenson MD, et al. (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium.". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID 9520111.  
  • Pishvaian MJ, Feltes CM, Thompson P, et al. (1999). "Cadherin-11 is expressed in invasive breast cancer cell lines.". Cancer Res. 59 (4): 947–52. PMID 10029089.  
  • Kawaguchi J, Takeshita S, Kashima T, et al. (1999). "Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11.". J. Bone Miner. Res. 14 (5): 764–75. doi:10.1359/jbmr.1999.14.5.764. PMID 10320525.  
  • Braungart E, Schumacher C, Hartmann E, et al. (2000). "Functional loss of E-cadherin and cadherin-11 alleles on chromosome 16q22 in colonic cancer.". J. Pathol. 187 (5): 530–4. doi:10.1002/(SICI)1096-9896(199904)187:5<530::AID-PATH293>3.0.CO;2-C. PMID 10398117.  
  • Kashima T, Kawaguchi J, Takeshita S, et al. (1999). "Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis.". Am. J. Pathol. 155 (5): 1549–55. PMID 10550312.  
  • Lecanda F, Cheng SL, Shin CS, et al. (2000). "Differential regulation of cadherins by dexamethasone in human osteoblastic cells.". J. Cell. Biochem. 77 (3): 499–506. doi:10.1002/(SICI)1097-4644(20000601)77:3<499::AID-JCB14>3.0.CO;2-0. PMID 10760957.  
  • Braungart E, Hartman E, Bechler K, et al. (2002). "The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation.". Cell Commun. Adhes. 8 (1): 15–27. doi:10.3109/15419060109080704. PMID 11775026.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Straub BK, Boda J, Kuhn C, et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.". J. Cell. Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.  
  • Morimoto AM, Tan N, West K, et al. (2004). "Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor.". Oncogene 23 (8): 1618–26. doi:10.1038/sj.onc.1207268. PMID 14985702.  
  • Marchong MN, Chen D, Corson TW, et al. (2005). "Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma.". Mol. Cancer Res. 2 (9): 495–503. PMID 15383628.  
  • Oliveira AM, Perez-Atayde AR, Inwards CY, et al. (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts.". Am. J. Pathol. 165 (5): 1773–80. PMID 15509545.  
  • Kiener HP, Brenner MB (2005). "Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion.". Arthritis Res. Ther. 7 (2): 49–54. doi:10.1186/ar1495. PMID 15743489.  
  • Kiener HP, Lee DM, Agarwal SK, Brenner MB (2006). "Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro.". Am. J. Pathol. 168 (5): 1486–99. doi:10.2353/ajpath.2006.050999. PMID 16651616.  


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