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Cadherin 12, type 2 (N-cadherin 2)
Symbols CDH12; CDHB; FLJ34857
External IDs OMIM600562 MGI109503 HomoloGene37873 GeneCards: CDH12 Gene
RNA expression pattern
PBB GE CDH12 207149 at tn.png
More reference expression data
Species Human Mouse
Entrez 1010 215654
Ensembl ENSG00000154162 ENSMUSG00000040452
UniProt P55289 n/a
RefSeq (mRNA) NM_004061 NM_001008420
RefSeq (protein) NP_004052 NP_001008420
Location (UCSC) Chr 5:
21.79 - 22.89 Mb
Chr 15:
21.06 - 21.53 Mb
PubMed search [1] [2]

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.[1][2]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.[2]


Further reading

  • Jean Weissenbach, Gyapay G, Dib C, et al. (1992). "A second-generation linkage map of the human genome.". Nature 359 (6398): 794–801. doi:10.1038/359794a0. PMID 1436057.  
  • Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.". Cell Regul. 2 (4): 261–70. PMID 2059658.  
  • Gyapay G, Morissette J, Vignal A, et al. (1994). "The 1993-94 Généthon human genetic linkage map.". Nat. Genet. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953.  
  • Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.". Cell Adhes. Commun. 2 (1): 15–26. doi:10.3109/15419069409014199. PMID 7982033.  
  • Selig S, Lidov HG, Bruno SA, et al. (1997). "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2398–403. doi:10.1073/pnas.94.6.2398. PMID 9122206.  
  • Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.  
  • Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma.". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.  
  • Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMID 10861224.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  


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