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Cadherin 15, M-cadherin (myotubule)
Symbols CDH15; MCAD; CDH3; CDH14; CDHM
External IDs OMIM114019 MGI106672 HomoloGene3622 GeneCards: CDH15 Gene
RNA expression pattern
PBB GE CDH15 206327 s at tn.png
PBB GE CDH15 206328 at tn.png
More reference expression data
Species Human Mouse
Entrez 1013 12555
Ensembl ENSG00000129910 ENSMUSG00000031962
UniProt P55291 P33146
RefSeq (mRNA) NM_004933 NM_007662
RefSeq (protein) NP_004924 NP_031688
Location (UCSC) Chr 16:
87.77 - 87.79 Mb
Chr 8:
125.73 - 125.75 Mb
PubMed search [1] [2]

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.[1][2]

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.[2]


CDH15 has been shown to interact with ARVCF.[3]


  1. ^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Dec 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488–90. PMID 1427864.  
  2. ^ a b "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)".  
  3. ^ Kaufmann, U; Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch B M, Eppenberger H, Starzinski-Powitz A (Nov. 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell. Sci. (ENGLAND) 113 ( Pt 22): 4121–35. ISSN 0021-9533. PMID 11058098.  

Further reading

  • Donalies M, Cramer M, Ringwald M, Starzinski-Powitz A (1991). "Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8024–8. doi:10.1073/pnas.88.18.8024. PMID 1840697.  
  • Bornemann A, Schmalbruch H (1994). "Immunocytochemistry of M-cadherin in mature and regenerating rat muscle.". Anat. Rec. 239 (2): 119–25. doi:10.1002/ar.1092390202. PMID 8059975.  
  • Shibata T, Shimoyama Y, Gotoh M, Hirohashi S (1997). "Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.". J. Biol. Chem. 272 (8): 5236–40. doi:10.1074/jbc.272.8.5236. PMID 9030594.  
  • Kuch C, Winnekendonk D, Butz S, et al. (1997). "M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells.". Exp. Cell Res. 232 (2): 331–8. doi:10.1006/excr.1997.3519. PMID 9168809.  
  • Shimoyama Y, Shibata T, Kitajima M, Hirohashi S (1998). "Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin.". J. Biol. Chem. 273 (16): 10011–8. doi:10.1074/jbc.273.16.10011. PMID 9545347.  
  • Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.  
  • Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMID 10861224.  
  • Kaufmann U, Zuppinger C, Waibler Z, et al. (2001). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions.". J. Cell. Sci. 113 ( Pt 22): 4121–35. PMID 11058098.  
  • Meigs TE, Fields TA, McKee DD, Casey PJ (2001). "Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 519–24. doi:10.1073/pnas.021350998. PMID 11136230.  
  • Hollnagel A, Grund C, Franke WW, Arnold HH (2002). "The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.". Mol. Cell. Biol. 22 (13): 4760–70. doi:10.1128/MCB.22.13.4760-4770.2002. PMID 12052883.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Kang JS, Feinleib JL, Knox S, et al. (2003). "Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3989–94. doi:10.1073/pnas.0736565100. PMID 12634428.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  


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