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Cadherin 17, LI cadherin (liver-intestine)
Identifiers
Symbols CDH17; CDH16; FLJ26931; HPT-1; HPT1; MGC138218; MGC142024
External IDs OMIM603017 MGI1095414 HomoloGene56859 GeneCards: CDH17 Gene
RNA expression pattern
PBB GE CDH17 209847 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1015 12557
Ensembl ENSG00000079112 ENSMUSG00000028217
UniProt Q12864 Q3TAN0
RefSeq (mRNA) NM_004063 NM_019753
RefSeq (protein) NP_004054 NP_062727
Location (UCSC) Chr 8:
95.21 - 95.29 Mb
Chr 4:
11.69 - 11.75 Mb
PubMed search [1] [2]

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[3]

References

  1. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467-71. doi:10.1006/geno.1998.5281. PMID 9615235.  
  2. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160-3. doi:10.1006/geno.1998.5717. PMID 10191097.  
  3. ^ a b "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1015.  

Further reading

  • Gessner R, Tauber R (2001). "Intestinal cell adhesion molecules. Liver-intestine cadherin.". Ann. N. Y. Acad. Sci. 915: 136–43. PMID 11193569.  
  • Gilston A (1978). "Reducing the hazard of disconnected tubes.". Anaesthesia 32 (9): 922. doi:10.1111/j.1365-2044.1977.tb10133.x. PMID 603017.  
  • Dantzig AH, Hoskins JA, Tabas LB, et al. (1994). "Association of intestinal peptide transport with a protein related to the cadherin superfamily.". Science 264 (5157): 430–3. doi:10.1126/science.8153632. PMID 8153632.  
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467.  
  • Grötzinger C, Kneifel J, Patschan D, et al. (2001). "LI-cadherin: a marker of gastric metaplasia and neoplasia.". Gut 49 (1): 73–81. doi:10.1136/gut.49.1.73. PMID 11413113.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Takamura M, Sakamoto M, Ino Y, et al. (2003). "Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas.". Cancer Sci. 94 (5): 425–30. doi:10.1111/j.1349-7006.2003.tb01459.x. PMID 12824888.  
  • Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin.". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.  
  • Ko S, Chu KM, Luk JM, et al. (2004). "Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis.". Biochem. Biophys. Res. Commun. 319 (2): 562–8. doi:10.1016/j.bbrc.2004.04.197. PMID 15178443.  
  • Takamura M, Ichida T, Matsuda Y, et al. (2004). "Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.". Cancer Lett. 212 (2): 253–9. doi:10.1016/j.canlet.2004.03.016. PMID 15279905.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Wang XQ, Luk JM, Leung PP, et al. (2005). "Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma.". Clin. Cancer Res. 11 (2 Pt 1): 483–9. PMID 15701831.  
  • Wang XQ, Luk JM, Garcia-Barcelo M, et al. (2007). "Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma.". Clin. Cancer Res. 12 (17): 5248–52. doi:10.1158/1078-0432.CCR-06-0558. PMID 16951245.  
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