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Cadherin 17, LI cadherin (liver-intestine)
Symbols CDH17; CDH16; FLJ26931; HPT-1; HPT1; MGC138218; MGC142024
External IDs OMIM603017 MGI1095414 HomoloGene56859 GeneCards: CDH17 Gene
RNA expression pattern
PBB GE CDH17 209847 at tn.png
More reference expression data
Species Human Mouse
Entrez 1015 12557
Ensembl ENSG00000079112 ENSMUSG00000028217
UniProt Q12864 Q3TAN0
RefSeq (mRNA) NM_004063 NM_019753
RefSeq (protein) NP_004054 NP_062727
Location (UCSC) Chr 8:
95.21 - 95.29 Mb
Chr 4:
11.69 - 11.75 Mb
PubMed search [1] [2]

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[3]


  1. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467-71. doi:10.1006/geno.1998.5281. PMID 9615235.  
  2. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160-3. doi:10.1006/geno.1998.5717. PMID 10191097.  
  3. ^ a b "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".  

Further reading

  • Gessner R, Tauber R (2001). "Intestinal cell adhesion molecules. Liver-intestine cadherin.". Ann. N. Y. Acad. Sci. 915: 136–43. PMID 11193569.  
  • Gilston A (1978). "Reducing the hazard of disconnected tubes.". Anaesthesia 32 (9): 922. doi:10.1111/j.1365-2044.1977.tb10133.x. PMID 603017.  
  • Dantzig AH, Hoskins JA, Tabas LB, et al. (1994). "Association of intestinal peptide transport with a protein related to the cadherin superfamily.". Science 264 (5157): 430–3. doi:10.1126/science.8153632. PMID 8153632.  
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMID 11337467.  
  • Grötzinger C, Kneifel J, Patschan D, et al. (2001). "LI-cadherin: a marker of gastric metaplasia and neoplasia.". Gut 49 (1): 73–81. doi:10.1136/gut.49.1.73. PMID 11413113.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Takamura M, Sakamoto M, Ino Y, et al. (2003). "Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas.". Cancer Sci. 94 (5): 425–30. doi:10.1111/j.1349-7006.2003.tb01459.x. PMID 12824888.  
  • Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin.". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.  
  • Ko S, Chu KM, Luk JM, et al. (2004). "Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis.". Biochem. Biophys. Res. Commun. 319 (2): 562–8. doi:10.1016/j.bbrc.2004.04.197. PMID 15178443.  
  • Takamura M, Ichida T, Matsuda Y, et al. (2004). "Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.". Cancer Lett. 212 (2): 253–9. doi:10.1016/j.canlet.2004.03.016. PMID 15279905.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Wang XQ, Luk JM, Leung PP, et al. (2005). "Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma.". Clin. Cancer Res. 11 (2 Pt 1): 483–9. PMID 15701831.  
  • Wang XQ, Luk JM, Garcia-Barcelo M, et al. (2007). "Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma.". Clin. Cancer Res. 12 (17): 5248–52. doi:10.1158/1078-0432.CCR-06-0558. PMID 16951245.  


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