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CDH3 (gene): Wikis


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Cadherin 3, type 1, P-cadherin (placental)
External IDs OMIM114021 MGI88356 HomoloGene20425 GeneCards: CDH3 Gene
RNA expression pattern
PBB GE CDH3 203256 at tn.png
More reference expression data
Species Human Mouse
Entrez 1001 12560
Ensembl ENSG00000062038 ENSMUSG00000061048
UniProt P22223 Q80VY6
RefSeq (mRNA) NM_001793 XM_001000165
RefSeq (protein) NP_001784 XP_001000165
Location (UCSC) Chr 16:
67.24 - 67.29 Mb
Chr 8:
109.4 - 109.45 Mb
PubMed search [1] [2]

Cadherin-3 is a protein that in humans is encoded by the CDH3 gene.[1][2]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.[2]


CDH3 (gene) has been shown to interact with CDH1,[3] Beta-catenin,[3][4] Plakoglobin,[3] Nephrin[5] and Catenin (cadherin-associated protein), alpha 1.[3][4]


  1. ^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Dec 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488–90. PMID 1427864.  
  2. ^ a b "Entrez Gene: CDH3 cadherin 3, type 1, P-cadherin (placental)".  
  3. ^ a b c d Klingelhöfer, J; Troyanovsky R B, Laur O Y, Troyanovsky S (Aug. 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". J. Cell. Sci. (ENGLAND) 113 ( Pt 16): 2829–36. ISSN 0021-9533. PMID 10910767.  
  4. ^ a b Schmeiser, K; Grand R J (Apr. 1999). "The fate of E- and P-cadherin during the early stages of apoptosis". Cell Death Differ. (ENGLAND) 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. ISSN 1350-9047. PMID 10381631.  
  5. ^ Lehtonen, Sanna; Lehtonen Eero, Kudlicka Krystyna, Holthöfer Harry, Farquhar Marilyn G (Sep. 2004). "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. (United States) 165 (3): 923–36. ISSN 0002-9440. PMID 15331416.  

Further reading

  • Herrenknecht K, Ozawa M, Eckerskorn C, et al. (1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9156–60. doi:10.1073/pnas.88.20.9156. PMID 1924379.  
  • Shimoyama Y, Hirohashi S, Hirano S, et al. (1989). "Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.". Cancer Res. 49 (8): 2128–33. PMID 2702654.  
  • Shimoyama Y, Yoshida T, Terada M, et al. (1989). "Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues.". J. Cell Biol. 109 (4 Pt 1): 1787–94. doi:10.1083/jcb.109.4.1787. PMID 2793940.  
  • Palacios J, Benito N, Pizarro A, et al. (1995). "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features.". Am. J. Pathol. 146 (3): 605–12. PMID 7534041.  
  • van der Linden PJ, de Goeij AF, Dunselman GA, et al. (1995). "Expression of cadherins and integrins in human endometrium throughout the menstrual cycle.". Fertil. Steril. 63 (6): 1210–6. PMID 7538474.  
  • Tang A, Eller MS, Hara M, et al. (1994). "E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro.". J. Cell. Sci. 107 ( Pt 4): 983–92. PMID 8056851.  
  • Tassin MT, Beziau A, Gubler MC, Boyer B (1994). "Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes.". Int. J. Dev. Biol. 38 (1): 45–54. PMID 8074995.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Navarro P, Lozano E, Cano A (1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin.". J. Cell. Sci. 105 ( Pt 4): 923–34. PMID 8227214.  
  • Reynolds AB, Daniel JM, Mo YY, et al. (1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts.". Exp. Cell Res. 225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID 8660921.  
  • Soler AP, Harner GD, Knudsen KA, et al. (1997). "Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology.". Am. J. Pathol. 151 (2): 471–8. PMID 9250159.  
  • Wakita H, Furukawa F, Baba S, Takigawa M (1997). "Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation.". Int. J. Cancer 73 (3): 432–9. doi:10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E. PMID 9359492.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.  
  • Jarrard DF, Paul R, van Bokhoven A, et al. (1999). "P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer.". Clin. Cancer Res. 3 (11): 2121–8. PMID 9815605.  
  • Schmeiser K, Grand RJ (1999). "The fate of E- and P-cadherin during the early stages of apoptosis.". Cell Death Differ. 6 (4): 377–86. doi:10.1038/sj.cdd.4400504. PMID 10381631.  
  • Rufas O, Fisch B, Ziv S, Shalgi R (2000). "Expression of cadherin adhesion molecules on human gametes.". Mol. Hum. Reprod. 6 (2): 163–9. doi:10.1093/molehr/6.2.163. PMID 10655458.  
  • Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions.". J. Cell. Sci. 113 ( Pt 16): 2829–36. PMID 10910767.  
  • Han AC, Edelson MI, Peralta Soler A, et al. (2000). "Cadherin expression in glandular tumors of the cervix.". Cancer 89 (10): 2053–8. doi:10.1002/1097-0142(20001115)89:10<2053::AID-CNCR4>3.0.CO;2-C. PMID 11066045.  


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