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Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

PDB rendering based on 2gk2.
Available structures
Symbols CEACAM1; BGP; BGP1; BGPI; CD66a
External IDs OMIM109770 MGI1347245 HomoloGene86044 GeneCards: CEACAM1 Gene
RNA expression pattern
PBB GE CEACAM1 206576 s at tn.png
PBB GE CEACAM1 209498 at tn.png
PBB GE CEACAM1 211883 x at tn.png
More reference expression data
Species Human Mouse
Entrez 634 26365
Ensembl ENSG00000079385 ENSMUSG00000074272
UniProt P13688 Q3LFS7
RefSeq (mRNA) NM_001024912 XM_989614
RefSeq (protein) NP_001020083 XP_994708
Location (UCSC) Chr 19:
47.7 - 47.72 Mb
Chr 7:
24.99 - 25.19 Mb
PubMed search [1] [2]

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human gene.[1]

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.[1]

In melanocytic cells CEACAM1 gene expression may be regulated by MITF[2].



CEACAM1 has been shown to interact with PTPN11[3] and Annexin A2.[4]

See also


  1. ^ a b "Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)".  
  2. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.  
  3. ^ Huber, M; Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N (Jan. 1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". J. Biol. Chem. (UNITED STATES) 274 (1): 335–44. ISSN 0021-9258. PMID 9867848.  
  4. ^ Kirshner, Julia; Schumann Detlef, Shively John E (Dec. 2003). "CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis". J. Biol. Chem. (United States) 278 (50): 50338–45. doi:10.1074/jbc.M309115200. ISSN 0021-9258. PMID 14522961.  

Further reading

  • Gray-Owen SD, Blumberg RS (2006). "CEACAM1: contact-dependent control of immunity.". Nat. Rev. Immunol. 6 (6): 433–46. doi:10.1038/nri1864. PMID 16724098.  
  • Svenberg T, Hammarström S, Zeromski J (1979). "Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues.". Clin. Exp. Immunol. 36 (3): 436–41. PMID 385181.  
  • Thompson J, Zimmermann W, Osthus-Bugat P, et al. (1992). "Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster.". Genomics 12 (4): 761–72. doi:10.1016/0888-7543(92)90307-E. PMID 1572649.  
  • Kuroki M, Arakawa F, Matsuo Y, et al. (1991). "Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library.". Biochem. Biophys. Res. Commun. 176 (2): 578–85. doi:10.1016/S0006-291X(05)80223-2. PMID 2025273.  
  • Hinoda Y, Neumaier M, Hefta SA, et al. (1988). "Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen.". Proc. Natl. Acad. Sci. U.S.A. 85 (18): 6959–63. doi:10.1073/pnas.85.18.6959. PMID 2457922.  
  • Barnett TR, Kretschmer A, Austen DA, et al. (1989). "Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family.". J. Cell Biol. 108 (2): 267–76. doi:10.1083/jcb.108.2.267. PMID 2537311.  
  • Neumaier M, Paululat S, Chan A, et al. (1993). "Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10744–8. doi:10.1073/pnas.90.22.10744. PMID 7504281.  
  • Formisano P, Najjar SM, Gross CN, et al. (1995). "Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase.". J. Biol. Chem. 270 (41): 24073–7. doi:10.1074/jbc.270.26.15844. PMID 7592607.  
  • Frängsmyr L, Baranov V, Prall F, et al. (1995). "Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa.". Cancer Res. 55 (14): 2963–7. PMID 7606710.  
  • Najjar SM, Philippe N, Suzuki Y, et al. (1995). "Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase.". Biochemistry 34 (29): 9341–9. doi:10.1021/bi00029a009. PMID 7626603.  
  • Nédellec P, Turbide C, Beauchemin N (1995). "Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene.". Eur. J. Biochem. 231 (1): 104–14. doi:10.1111/j.1432-1033.1995.tb20676.x. PMID 7628460.  
  • Watt SM, Fawcett J, Murdoch SJ, et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant.". Blood 84 (1): 200–10. PMID 8018919.  
  • Hauck W, Nédellec P, Turbide C, et al. (1994). "Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas.". Eur. J. Biochem. 223 (2): 529–41. doi:10.1111/j.1432-1033.1994.tb19022.x. PMID 8055923.  
  • Barnett TR, Drake L, Pickle W (1993). "Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins.". Mol. Cell. Biol. 13 (2): 1273–82. PMID 8423792.  
  • Kuroki M, Yamanaka T, Matsuo Y, et al. (1996). "Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils.". Immunol. Invest. 24 (5): 829–43. doi:10.3109/08820139509060710. PMID 8543346.  
  • Huber M, Izzi L, Grondin P, et al. (1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells.". J. Biol. Chem. 274 (1): 335–44. doi:10.1074/jbc.274.1.335. PMID 9867848.  
  • Feuk-Lagerstedt E, Jordan ET, Leffler H, et al. (1999). "Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils.". J. Immunol. 163 (10): 5592–8. PMID 10553088.  
  • Soni P, Lakkis M, Poy MN, et al. (2000). "The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor.". Mol. Cell. Biol. 20 (11): 3896–905. doi:10.1128/MCB.20.11.3896-3905.2000. PMID 10805733.  
  • Ergün S, Kilik N, Ziegeler G, et al. (2000). "CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor.". Mol. Cell 5 (2): 311–20. doi:10.1016/S1097-2765(00)80426-8. PMID 10882072.  
  • Wang L, Lin SH, Wu WG, et al. (2000). "C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers.". Clin. Cancer Res. 6 (8): 2988–93. PMID 10955775.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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