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Carcinoembryonic antigen-related cell adhesion molecule 3
Symbols CEACAM3; CEA; CD66D; CGM1; MGC119875; W264; W282
External IDs OMIM609142 MGI1347248 HomoloGene86055 GeneCards: CEACAM3 Gene
RNA expression pattern
PBB GE CEACAM3 208052 x at tn.png
PBB GE CEACAM3 210789 x at tn.png
More reference expression data
Species Human Mouse
Entrez 1084 26366
Ensembl ENSG00000170956 ENSMUSG00000054169
UniProt P40198 Q61400
RefSeq (mRNA) NM_001815 NM_007675
RefSeq (protein) NP_001806 NP_031701
Location (UCSC) Chr 19:
46.99 - 47.01 Mb
Chr 7:
24.49 - 24.49 Mb
PubMed search [1] [2]

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a human gene.[1]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]


See also


Further reading

  • Khan WN, Frängsmyr L, Teglund S, et al. (1992). "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.". Genomics 14 (2): 384–90. doi:10.1016/S0888-7543(05)80230-7. PMID 1427854.  
  • Kuroki M, Arakawa F, Matsuo Y, et al. (1991). "Molecular cloning of nonspecific cross-reacting antigens in human granulocytes.". J. Biol. Chem. 266 (18): 11810–7. PMID 2050678.  
  • Thompson JA, Mauch EM, Chen FS, et al. (1989). "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons.". Biochem. Biophys. Res. Commun. 158 (3): 996–1004. doi:10.1016/0006-291X(89)92821-0. PMID 2537643.  
  • Watt SM, Fawcett J, Murdoch SJ, et al. (1994). "CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant.". Blood 84 (1): 200–10. PMID 8018919.  
  • Nagel G, Grunert F, Kuijpers TW, et al. (1993). "Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family.". Eur. J. Biochem. 214 (1): 27–35. doi:10.1111/j.1432-1033.1993.tb17892.x. PMID 8508798.  
  • Skubitz KM, Campbell KD, Skubitz AP (1996). "CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils.". J. Leukoc. Biol. 60 (1): 106–17. PMID 8699114.  
  • Streichert T, Ebrahimnejad A, Ganzer S, et al. (2001). "The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes.". Biochem. Biophys. Res. Commun. 289 (1): 191–7. doi:10.1006/bbrc.2001.5955. PMID 11708798.  
  • Skubitz KM, Campbell KD, Skubitz AP (2002). "Synthetic peptides from the N-domains of CEACAMs activate neutrophils.". J. Pept. Res. 58 (6): 515–26. doi:10.1034/j.1399-3011.2001.00931.x. PMID 12005421.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Booth JW, Telio D, Liao EH, et al. (2003). "Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae.". J. Biol. Chem. 278 (16): 14037–45. doi:10.1074/jbc.M211879200. PMID 12571236.  
  • McCaw SE, Schneider J, Liao EH, et al. (2003). "Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.". Mol. Microbiol. 49 (3): 623–37. doi:10.1046/j.1365-2958.2003.03591.x. PMID 12864848.  
  • Schmitter T, Agerer F, Peterson L, et al. (2004). "Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens.". J. Exp. Med. 199 (1): 35–46. doi:10.1084/jem.20030204. PMID 14707113.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Gimbergues P, Dauplat MM, Cayre A, et al. (2007). "Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category.". Eur J Surg Oncol 33 (1): 16–22. doi:10.1016/j.ejso.2006.09.013. PMID 17071045.  
  • Gasser M, Gerstlauer C, Grimm M, et al. (2007). "Comparative analysis of predictive biomarkers for therapeutical strategies in colorectal cancer.". Ann. Surg. Oncol. 14 (4): 1272–84. doi:10.1245/s10434-006-9155-0. PMID 17211733.  
  • Howell NR, Zheng W, Cheng L, et al. (2007). "Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?". Int. J. Gynecol. Pathol. 26 (2): 134–40. doi:10.1097/01.pgp.0000233166.56385.d0. PMID 17413979.  
  • Stern-Ginossar N, Nedvetzki S, Markel G, et al. (2007). "Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells.". J. Immunol. 179 (7): 4424–34. PMID 17878338.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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