CEBPB: Wikis

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CCAAT/enhancer binding protein (C/EBP), beta

PDB rendering based on 1ci6.
Available structures
1ci6, 1gtw, 1gu4, 1gu5, 1h88, 1h89, 1h8a, 1hjb, 1io4
Identifiers
Symbols CEBPB; C/EBP-beta; CRP2; IL6DBP; LAP; MGC32080; NF-IL6; TCF5
External IDs OMIM189965 MGI88373 HomoloGene3807 GeneCards: CEBPB Gene
RNA expression pattern
PBB GE CEBPB 212501 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1051 12608
Ensembl ENSG00000172216 ENSMUSG00000056501
UniProt P17676 Q3UPN9
RefSeq (mRNA) NM_005194 NM_009883
RefSeq (protein) NP_005185 NP_034013
Location (UCSC) Chr 20:
48.24 - 48.24 Mb
Chr 2:
167.38 - 167.38 Mb
PubMed search [1] [2]

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.[1][2]

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.[3]

Contents

See also

Interactions

CEBPB has been shown to interact with CREB1,[4] Sp1 transcription factor,[5][6] Glucocorticoid receptor,[7] Nucleolar phosphoprotein p130,[8] DNA damage-inducible transcript 3,[9][10] HSF1,[11] RELA,[12][13] Zif268,[14] TRIM28,[15][16] SMARCA2,[17] Estrogen receptor alpha,[7][18] EP300,[19] HMGA1,[6] CRSP3[20] and Serum response factor.[21][22]

References

  1. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (Jul 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.  
  2. ^ Cao Z, Umek RM, McKnight SL (Oct 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.  
  3. ^ "Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1051.  
  4. ^ Chen, Yongchang; Zhuang Shunhui, Cassenaer Stijn, Casteel Darren E, Gudi Tanima, Boss Gerry R, Pilz Renate B (Jun. 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Mol. Cell. Biol. (United States) 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. ISSN 0270-7306. PMID 12773552.  
  5. ^ Liu, Yi-Wen; Tseng Hui-Ping, Chen Lei-Chin, Chen Ben-Kuen, Chang Wen-Chang (Jul. 2003). "Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages". J. Immunol. (United States) 171 (2): 821–8. ISSN 0022-1767. PMID 12847250.  
  6. ^ a b Foti, Daniela; Iuliano Rodolfo, Chiefari Eusebio, Brunetti Antonio (Apr. 2003). "A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription". Mol. Cell. Biol. (United States) 23 (8): 2720–32. doi:10.1128/MCB.23.8.2720-2732.2003. ISSN 0270-7306. PMID 12665574.  
  7. ^ a b Boruk, M; Savory J G, Haché R J (Nov. 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor". Mol. Endocrinol. (UNITED STATES) 12 (11): 1749–63. doi:10.1210/me.12.11.1749. ISSN 0888-8809. PMID 9817600.  
  8. ^ Miau, L H; Chang C J, Shen B J, Tsai W H, Lee S C (Apr. 1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. (UNITED STATES) 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. ISSN 0021-9258. PMID 9553145.  
  9. ^ Hattori, Takayuki; Ohoka Nobumichi, Hayashi Hidetoshi, Onozaki Kikuo (Apr. 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. (Netherlands) 541 (1-3): 33–9. doi:10.1016/S0014-5793(03)00283-7. ISSN 0014-5793. PMID 12706815.  
  10. ^ Fawcett, T W; Eastman H B, Martindale J L, Holbrook N J (Jun. 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. (UNITED STATES) 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. ISSN 0021-9258. PMID 8662954.  
  11. ^ Xie, Yue; Chen Changmin, Stevenson Mary Ann, Auron Philip E, Calderwood Stuart K (Apr. 2002). "Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6". J. Biol. Chem. (United States) 277 (14): 11802–10. doi:10.1074/jbc.M109296200. ISSN 0021-9258. PMID 11801594.  
  12. ^ Weber, Marion; Sydlik Carmen, Quirling Martina, Nothdurfter Caroline, Zwergal Andreas, Heiss Peter, Bell Susanne, Neumeier Dieter, Ziegler-Heitbrock H W Loms, Brand Korbinian (Jun. 2003). "Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta". J. Biol. Chem. (United States) 278 (26): 23586–93. doi:10.1074/jbc.M211646200. ISSN 0021-9258. PMID 12707271.  
  13. ^ Xia, C; Cheshire J K, Patel H, Woo P (Dec. 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". Int. J. Biochem. Cell Biol. (ENGLAND) 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. ISSN 1357-2725. PMID 9570146.  
  14. ^ Zhang, Fang; Lin Meihong, Abidi Parveen, Thiel Gerald, Liu Jingwen (Nov. 2003). "Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene". J. Biol. Chem. (United States) 278 (45): 44246–54. doi:10.1074/jbc.M305564200. ISSN 0021-9258. PMID 12947119.  
  15. ^ Rooney, J W; Calame K L (Nov. 2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937". Genes Dev. (United States) 15 (22): 3023–38. doi:10.1101/gad.937201. ISSN 0890-9369. PMID 11711437.  
  16. ^ Chang, C J; Chen Y L, Lee S C (Oct. 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression". Mol. Cell. Biol. (UNITED STATES) 18 (10): 5880–7. ISSN 0270-7306. PMID 9742105.  
  17. ^ Kowenz-Leutz, E; Leutz A (Nov. 1999). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes". Mol. Cell (UNITED STATES) 4 (5): 735–43. doi:10.1016/S1097-2765(00)80384-6. ISSN 1097-2765. PMID 10619021.  
  18. ^ Stein, B; Yang M X (Sep. 1995). "Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4971–9. ISSN 0270-7306. PMID 7651415.  
  19. ^ Mink, S; Haenig B, Klempnauer K H (Nov. 1997). "Interaction and functional collaboration of p300 and C/EBPbeta". Mol. Cell. Biol. (UNITED STATES) 17 (11): 6609–17. ISSN 0270-7306. PMID 9343424.  
  20. ^ Mo, Xianming; Kowenz-Leutz Elisabeth, Xu Hong, Leutz Achim (Jan. 2004). "Ras induces mediator complex exchange on C/EBP beta". Mol. Cell (United States) 13 (2): 241–50. doi:10.1016/S1097-2765(03)00521-5. ISSN 1097-2765. PMID 14759369.  
  21. ^ Hanlon, M; Sealy L (May. 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta". J. Biol. Chem. (UNITED STATES) 274 (20): 14224–8. doi:10.1074/jbc.274.20.14224. ISSN 0021-9258. PMID 10318842.  
  22. ^ Sealy, L; Malone D, Pawlak M (Mar. 1997). "Regulation of the cfos serum response element by C/EBPbeta". Mol. Cell. Biol. (UNITED STATES) 17 (3): 1744–55. ISSN 0270-7306. PMID 9032301.  

Further reading

  • Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.  
  • Maytin EV, Habener JF (1998). "Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo.". J. Invest. Dermatol. 110 (3): 238–46. doi:10.1046/j.1523-1747.1998.00123.x. PMID 9506442.  
  • Cornwall GA, Hsia N (2003). "[Cres (cystatin-related epididymal spermatogenic) gene regulation and function]". Zhonghua Nan Ke Xue 8 (5): 313–8. PMID 12479114.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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