CEBPB: Wikis


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CCAAT/enhancer binding protein (C/EBP), beta

PDB rendering based on 1ci6.
Available structures
1ci6, 1gtw, 1gu4, 1gu5, 1h88, 1h89, 1h8a, 1hjb, 1io4
Symbols CEBPB; C/EBP-beta; CRP2; IL6DBP; LAP; MGC32080; NF-IL6; TCF5
External IDs OMIM189965 MGI88373 HomoloGene3807 GeneCards: CEBPB Gene
RNA expression pattern
PBB GE CEBPB 212501 at tn.png
More reference expression data
Species Human Mouse
Entrez 1051 12608
Ensembl ENSG00000172216 ENSMUSG00000056501
UniProt P17676 Q3UPN9
RefSeq (mRNA) NM_005194 NM_009883
RefSeq (protein) NP_005185 NP_034013
Location (UCSC) Chr 20:
48.24 - 48.24 Mb
Chr 2:
167.38 - 167.38 Mb
PubMed search [1] [2]

CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.[1][2]

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.[3]


See also


CEBPB has been shown to interact with CREB1,[4] Sp1 transcription factor,[5][6] Glucocorticoid receptor,[7] Nucleolar phosphoprotein p130,[8] DNA damage-inducible transcript 3,[9][10] HSF1,[11] RELA,[12][13] Zif268,[14] TRIM28,[15][16] SMARCA2,[17] Estrogen receptor alpha,[7][18] EP300,[19] HMGA1,[6] CRSP3[20] and Serum response factor.[21][22]


  1. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (Jul 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.  
  2. ^ Cao Z, Umek RM, McKnight SL (Oct 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.  
  3. ^ "Entrez Gene: CEBPB CCAAT/enhancer binding protein (C/EBP), beta".  
  4. ^ Chen, Yongchang; Zhuang Shunhui, Cassenaer Stijn, Casteel Darren E, Gudi Tanima, Boss Gerry R, Pilz Renate B (Jun. 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Mol. Cell. Biol. (United States) 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. ISSN 0270-7306. PMID 12773552.  
  5. ^ Liu, Yi-Wen; Tseng Hui-Ping, Chen Lei-Chin, Chen Ben-Kuen, Chang Wen-Chang (Jul. 2003). "Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages". J. Immunol. (United States) 171 (2): 821–8. ISSN 0022-1767. PMID 12847250.  
  6. ^ a b Foti, Daniela; Iuliano Rodolfo, Chiefari Eusebio, Brunetti Antonio (Apr. 2003). "A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription". Mol. Cell. Biol. (United States) 23 (8): 2720–32. doi:10.1128/MCB.23.8.2720-2732.2003. ISSN 0270-7306. PMID 12665574.  
  7. ^ a b Boruk, M; Savory J G, Haché R J (Nov. 1998). "AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor". Mol. Endocrinol. (UNITED STATES) 12 (11): 1749–63. doi:10.1210/me.12.11.1749. ISSN 0888-8809. PMID 9817600.  
  8. ^ Miau, L H; Chang C J, Shen B J, Tsai W H, Lee S C (Apr. 1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. (UNITED STATES) 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. ISSN 0021-9258. PMID 9553145.  
  9. ^ Hattori, Takayuki; Ohoka Nobumichi, Hayashi Hidetoshi, Onozaki Kikuo (Apr. 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. (Netherlands) 541 (1-3): 33–9. doi:10.1016/S0014-5793(03)00283-7. ISSN 0014-5793. PMID 12706815.  
  10. ^ Fawcett, T W; Eastman H B, Martindale J L, Holbrook N J (Jun. 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. (UNITED STATES) 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. ISSN 0021-9258. PMID 8662954.  
  11. ^ Xie, Yue; Chen Changmin, Stevenson Mary Ann, Auron Philip E, Calderwood Stuart K (Apr. 2002). "Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6". J. Biol. Chem. (United States) 277 (14): 11802–10. doi:10.1074/jbc.M109296200. ISSN 0021-9258. PMID 11801594.  
  12. ^ Weber, Marion; Sydlik Carmen, Quirling Martina, Nothdurfter Caroline, Zwergal Andreas, Heiss Peter, Bell Susanne, Neumeier Dieter, Ziegler-Heitbrock H W Loms, Brand Korbinian (Jun. 2003). "Transcriptional inhibition of interleukin-8 expression in tumor necrosis factor-tolerant cells: evidence for involvement of C/EBP beta". J. Biol. Chem. (United States) 278 (26): 23586–93. doi:10.1074/jbc.M211646200. ISSN 0021-9258. PMID 12707271.  
  13. ^ Xia, C; Cheshire J K, Patel H, Woo P (Dec. 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". Int. J. Biochem. Cell Biol. (ENGLAND) 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. ISSN 1357-2725. PMID 9570146.  
  14. ^ Zhang, Fang; Lin Meihong, Abidi Parveen, Thiel Gerald, Liu Jingwen (Nov. 2003). "Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene". J. Biol. Chem. (United States) 278 (45): 44246–54. doi:10.1074/jbc.M305564200. ISSN 0021-9258. PMID 12947119.  
  15. ^ Rooney, J W; Calame K L (Nov. 2001). "TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937". Genes Dev. (United States) 15 (22): 3023–38. doi:10.1101/gad.937201. ISSN 0890-9369. PMID 11711437.  
  16. ^ Chang, C J; Chen Y L, Lee S C (Oct. 1998). "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression". Mol. Cell. Biol. (UNITED STATES) 18 (10): 5880–7. ISSN 0270-7306. PMID 9742105.  
  17. ^ Kowenz-Leutz, E; Leutz A (Nov. 1999). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes". Mol. Cell (UNITED STATES) 4 (5): 735–43. doi:10.1016/S1097-2765(00)80384-6. ISSN 1097-2765. PMID 10619021.  
  18. ^ Stein, B; Yang M X (Sep. 1995). "Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta". Mol. Cell. Biol. (UNITED STATES) 15 (9): 4971–9. ISSN 0270-7306. PMID 7651415.  
  19. ^ Mink, S; Haenig B, Klempnauer K H (Nov. 1997). "Interaction and functional collaboration of p300 and C/EBPbeta". Mol. Cell. Biol. (UNITED STATES) 17 (11): 6609–17. ISSN 0270-7306. PMID 9343424.  
  20. ^ Mo, Xianming; Kowenz-Leutz Elisabeth, Xu Hong, Leutz Achim (Jan. 2004). "Ras induces mediator complex exchange on C/EBP beta". Mol. Cell (United States) 13 (2): 241–50. doi:10.1016/S1097-2765(03)00521-5. ISSN 1097-2765. PMID 14759369.  
  21. ^ Hanlon, M; Sealy L (May. 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta". J. Biol. Chem. (UNITED STATES) 274 (20): 14224–8. doi:10.1074/jbc.274.20.14224. ISSN 0021-9258. PMID 10318842.  
  22. ^ Sealy, L; Malone D, Pawlak M (Mar. 1997). "Regulation of the cfos serum response element by C/EBPbeta". Mol. Cell. Biol. (UNITED STATES) 17 (3): 1744–55. ISSN 0270-7306. PMID 9032301.  

Further reading

  • Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.  
  • Maytin EV, Habener JF (1998). "Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo.". J. Invest. Dermatol. 110 (3): 238–46. doi:10.1046/j.1523-1747.1998.00123.x. PMID 9506442.  
  • Cornwall GA, Hsia N (2003). "[Cres (cystatin-related epididymal spermatogenic) gene regulation and function]". Zhonghua Nan Ke Xue 8 (5): 313–8. PMID 12479114.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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