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CCAAT/enhancer binding protein (C/EBP), delta
Identifiers
Symbols CEBPD; C/EBP-delta; CELF; CRP3; NF-IL6-beta
External IDs OMIM116898 MGI103573 HomoloGene3808 GeneCards: CEBPD Gene
Orthologs
Species Human Mouse
Entrez 1052 12609
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) NM_005195 NM_007679
RefSeq (protein) NP_005186 NP_031705
Location (UCSC) n/a n/a
PubMed search [1] [2]

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]

Contents

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[4]

See also

References

  1. ^ Cao Z, Umek RM, McKnight SL (Oct 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes Dev 5 (9): 1538–52. PMID 1840554.  
  2. ^ Williams SC, Cantwell CA, Johnson PF (Oct 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev 5 (9): 1553–67. PMID 1884998.  
  3. ^ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1052.  
  4. ^ Choy, Lisa; Derynck Rik (Mar. 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". J. Biol. Chem. (United States) 278 (11): 9609–19. doi:10.1074/jbc.M212259200. ISSN 0021-9258. PMID 12524424.  

Further reading

  • Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.  
  • Kinoshita S, Akira S, Kishimoto T (1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1473–6. doi:10.1073/pnas.89.4.1473. PMID 1741402.  
  • Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).". J. Immunol. 155 (9): 4330–8. PMID 7594592.  
  • Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p.". Cytogenet. Cell Genet. 70 (3-4): 188–91. doi:10.1159/000134030. PMID 7789168.  
  • Cleutjens CB, van Eekelen CC, van Dekken H, et al. (1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization.". Genomics 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590.  
  • Chen PL, Riley DJ, Chen Y, Lee WH (1997). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.". Genes Dev. 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919.  
  • Xia C, Cheshire JK, Patel H, Woo P (1998). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes.". Int. J. Biochem. Cell Biol. 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.  
  • Zhu Y, Saunders MA, Yeh H, et al. (2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins.". J. Biol. Chem. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938.  
  • Angeloni D, Lee JD, Johnson BE, et al. (2002). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2.". Mol. Cell. Probes 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384.  
  • Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters.". J. Biol. Chem. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Dearth LR, DeWille J (2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells.". J. Biol. Chem. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732.  
  • Milde-Langosch K, Löning T, Bamberger AM (2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins.". Breast Cancer Res. Treat. 79 (2): 175–85. doi:10.1023/A:1023929504884. PMID 12825852.  
  • Kovács KA, Steinmann M, Magistretti PJ, et al. (2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation.". J. Biol. Chem. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754.  
  • Chen YW, Hubal MJ, Hoffman EP, et al. (2004). "Molecular responses of human muscle to eccentric exercise.". J. Appl. Physiol. 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035.  
  • Li R, Strohmeyer R, Liang Z, et al. (2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease.". Neurobiol. Aging 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823.  
  • Sivko GS, Sanford DC, Dearth LD, et al. (2005). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control.". J. Cell. Biochem. 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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