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CCAAT/enhancer binding protein (C/EBP), epsilon
Symbols CEBPE; C/EBP-epsilon; CRP1
External IDs OMIM600749 MGI103572 HomoloGene1367 GeneCards: CEBPE Gene
RNA expression pattern
PBB GE CEBPE 214523 at tn.png
More reference expression data
Species Human Mouse
Entrez 1053 110794
Ensembl ENSG00000092067 ENSMUSG00000052435
UniProt Q15744 Q32MW8
RefSeq (mRNA) NM_001805 XM_989335
RefSeq (protein) NP_001796 XP_994429
Location (UCSC) Chr 14:
22.66 - 22.66 Mb
Chr 14:
53.66 - 53.67 Mb
PubMed search [1] [2]

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CHOP, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene.[1][2] It is pro-apoptotic.[3]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[1]


  1. ^ a b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon".  
  2. ^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (July 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.  
  3. ^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". J. Biol. Chem. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405.  

Further reading

  • Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.  
  • Gombart AF, Koeffler HP (2002). "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon).". Curr. Opin. Hematol. 9 (1): 36–42. doi:10.1097/00062752-200201000-00007. PMID 11753076.  
  • Williams SC, Cantwell CA, Johnson PF (1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.". Genes Dev. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.  
  • Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus.". Genomics 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.  
  • Chumakov AM, Grillier I, Chumakova E, et al. (1997). "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor.". Mol. Cell. Biol. 17 (3): 1375–86. PMID 9032264.  
  • Yamanaka R, Kim GD, Radomska HS, et al. (1997). "CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing.". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6462–7. doi:10.1073/pnas.94.12.6462. PMID 9177240.  
  • Verbeek W, Gombart AF, Chumakov AM, et al. (1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.". Blood 93 (10): 3327–37. PMID 10233885.  
  • Lekstrom-Himes JA, Dorman SE, Kopar P, et al. (1999). "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon.". J. Exp. Med. 189 (11): 1847–52. doi:10.1084/jem.189.11.1847. PMID 10359588.  
  • Tavor S, Vuong PT, Park DJ, et al. (2002). "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.". Blood 99 (5): 1794–801. doi:10.1182/blood.V99.5.1794. PMID 11861297.  
  • Zhang P, Nelson E, Radomska HS, et al. (2002). "Induction of granulocytic differentiation by 2 pathways.". Blood 99 (12): 4406–12. doi:10.1182/blood.V99.12.4406. PMID 12036869.  
  • Kim J, Cantwell CA, Johnson PF, et al. (2002). "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.". J. Biol. Chem. 277 (41): 38037–44. doi:10.1074/jbc.M207235200. PMID 12161447.  
  • Du J, Stankiewicz MJ, Liu Y, et al. (2003). "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein.". J. Biol. Chem. 277 (45): 43481–94. doi:10.1074/jbc.M204777200. PMID 12202480.  
  • Truong BT, Lee YJ, Lodie TA, et al. (2003). "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.". Blood 101 (3): 1141–8. doi:10.1182/blood-2002-05-1374. PMID 12393450.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gombart AF, Kwok SH, Anderson KL, et al. (2003). "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.". Blood 101 (8): 3265–73. doi:10.1182/blood-2002-04-1039. PMID 12515729.  
  • Khanna-Gupta A, Zibello T, Sun H, et al. (2003). "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression.". Blood 101 (9): 3460–8. doi:10.1182/blood-2002-09-2767. PMID 12522000.  
  • Gery S, Gombart AF, Fung YK, Koeffler HP (2004). "C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.". Blood 103 (3): 828–35. doi:10.1182/blood-2003-01-0159. PMID 12947005.  
  • Gery S, Park DJ, Vuong PT, et al. (2005). "Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.". Blood 104 (13): 3911–7. doi:10.1182/blood-2003-10-3688. PMID 15308577.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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