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CGS-9896: Wikis

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CGS-9896
Systematic (IUPAC) name
2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
Identifiers
CAS number 77779-36-3
ATC code  ?
PubChem 108030
Chemical data
Formula C 16H10ClN3O 
Mol. mass 295.7231 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]

CGS-9896 is a benzodiazepine receptor partial agonist, which produces long-lasting anxiolytic and anticonvulsant effects in animal studies, but does not produce sedative effects.[2][3] It also increases appetite,[4] and reduces the development of gastrointestinal ulcers following chronic stress.[5]

References

  1. ^ Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-3057(88)90342-5. PMID 2854261. http://linkinghub.elsevier.com/retrieve/pii/0091-3057(88)90342-5.  
  2. ^ Bernasconi R, Marescaux C, Vergnes M, et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01259406. PMID 3343593.  
  3. ^ Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch Toxicol. 64 (5): 412–3. doi:10.1007/BF01973465. PMID 2206111.  
  4. ^ Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2-3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID 7667375. http://linkinghub.elsevier.com/retrieve/pii/0091-3057(95)00020-W.  
  5. ^ Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-1681.1990.tb01298.x. PMID 2109664.  
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