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Cholinergic receptor, nicotinic, alpha 2 (neuronal)
Symbols CHRNA2;
External IDs OMIM118502 MGI87886 HomoloGene20193 GeneCards: CHRNA2 Gene
RNA expression pattern
PBB GE CHRNA2 207868 at tn.png
More reference expression data
Species Human Mouse
Entrez 1135 110902
Ensembl ENSG00000120903 ENSMUSG00000022041
UniProt Q15822 Q8VI12
RefSeq (mRNA) NM_000742 NM_144803
RefSeq (protein) NP_000733 NP_659052
Location (UCSC) Chr 8:
27.37 - 27.39 Mb
Chr 14:
65.1 - 65.11 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit alpha-2 is a protein that in humans is encoded by the CHRNA2 gene.[1][2]


See also


  1. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962-7. PMID 1505988.  
  2. ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)".  

Further reading

  • Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function.". Rev. Physiol. Biochem. Pharmacol. 147: 1–46. doi:10.1007/s10254-003-0005-1. PMID 12783266.  
  • Wood S, Schertzer M, Yaremko ML (1995). "Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA.". Somat. Cell Mol. Genet. 21 (2): 147–50. doi:10.1007/BF02255790. PMID 7570187.  
  • García-Colunga J, Miledi R (1995). "Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors.". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2919–23. doi:10.1073/pnas.92.7.2919. PMID 7708749.  
  • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.  
  • Chavez-Noriega LE, Crona JH, Washburn MS, et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.". J. Pharmacol. Exp. Ther. 280 (1): 346–56. PMID 8996215.  
  • Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. PMID 9193799.  
  • Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173.  
  • Bertrand D, Picard F, Le Hellard S, et al. (2002). "How mutations in the nAChRs can cause ADNFLE epilepsy.". Epilepsia 43 Suppl 5: 112–22. doi:10.1046/j.1528-1157.43.s.5.16.x. PMID 12121305.  
  • Jin P, Fu GK, Wilson AD, et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.". Genomics 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.  
  • Aridon P, Marini C, Di Resta C, et al. (2006). "Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear.". Am. J. Hum. Genet. 79 (2): 342–50. doi:10.1086/506459. PMID 16826524.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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