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Cholinergic receptor, nicotinic, alpha 5
Symbols CHRNA5;
External IDs OMIM118505 MGI87889 HomoloGene55485 GeneCards: CHRNA5 Gene
RNA expression pattern
PBB GE CHRNA5 206533 at tn.png
More reference expression data
Species Human Mouse
Entrez 1138 110835
Ensembl ENSG00000169684 ENSMUSG00000035594
UniProt P30532 n/a
RefSeq (mRNA) NM_000745 XM_973541
RefSeq (protein) NP_000736 XP_978635
Location (UCSC) Chr 15:
76.64 - 76.67 Mb
Chr 9:
54.78 - 54.81 Mb
PubMed search [1] [2]

Neuronal acetylcholine receptor subunit alpha-5 is a protein that in humans is encoded by the CHRNA5 gene.[1][2]

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs.[supplied by OMIM][2]


See also


  1. ^ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics 9 (2): 278-82. PMID 2004777.  
  2. ^ a b "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5".  

Further reading

  • Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function.". Rev. Physiol. Biochem. Pharmacol. 147: 1–46. doi:10.1007/s10254-003-0005-1. PMID 12783266.  
  • Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.". Genomics 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.  
  • Chini B, Clementi F, Hukovic N, Sher E (1992). "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1572–6. PMID 1542648.  
  • Raimondi E, Rubboli F, Moralli D, et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits.". Genomics 12 (4): 849–50. PMID 1572664.  
  • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217–28. PMID 8906617.  
  • Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220.  
  • Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. PMID 9193799.  
  • Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors.". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874.  
  • Lentz TL (2000). "Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits.". Biochem. Biophys. Res. Commun. 268 (2): 480–4. doi:10.1006/bbrc.2000.2155. PMID 10679230.  
  • Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach.". Br. J. Pharmacol. 134 (4): 789–96. doi:10.1038/sj.bjp.0704313. PMID 11606319.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Soldà G, Boi S, Duga S, et al. (2005). "In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.". Gene 345 (2): 155–64. doi:10.1016/j.gene.2004.12.005. PMID 15716100.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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