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Cholinergic receptor, nicotinic, alpha 6
Symbols CHRNA6; CHNRA6
External IDs OMIM606888 MGI106213 HomoloGene20888 GeneCards: CHRNA6 Gene
RNA expression pattern
PBB GE CHRNA6 207568 at tn.png
More reference expression data
Species Human Mouse
Entrez 8973 11440
Ensembl ENSG00000147434 ENSMUSG00000031491
UniProt Q15825 Q3UEY4
RefSeq (mRNA) NM_004198 NM_021369
RefSeq (protein) NP_004189 NP_067344
Location (UCSC) Chr 8:
42.73 - 42.74 Mb
Chr 8:
28.87 - 28.88 Mb
PubMed search [1] [2]

Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, is a human gene,[1] which codes for the α6 subunit found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain,[2] and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine.[3][4][5] Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.[6][7]


See also


  1. ^ "Entrez Gene: CHRNA6 cholinergic receptor, nicotinic, alpha 6".  
  2. ^ Meyer EL, Yoshikami D, McIntosh JM. The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices. Journal of Neurochemistry. 2008 Jun;105(5):1761-9. PMID 18248619
  3. ^ Calabresi P, Massimiliano DF. ACh/Dopamine Crosstalk in Motor Control and Reward: A Crucial Role for α6-Containing Nicotinic Receptors? Neuron. 2008 Oct; 60(1):4-7.
  4. ^ Drenan RM, Grady SR, Whiteaker P, McClure-Begley T, McKinney S, Miwa JM, Bupp S, Heintz N, McIntosh JM, Bencherif M, Marks MJ, Lester HA. In Vivo Activation of Midbrain Dopamine Neurons via Sensitized, High-Affinity α6 Nicotinic Acetylcholine Receptors. Neuron. 2008 Oct; 60(1):123-136.
  5. ^ Exley R, Clements MA, Hartung H, McIntosh JM, Cragg SJ. Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66. PMID 18033235
  6. ^ Quik M, McIntosh JM. Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy. Journal of Pharmacology and Experimental Therapeutics. 2006 Feb;316(2):481-9. PMID 16210393
  7. ^ Bordia T, Grady SR, McIntosh JM, Quik M. Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum. Molecular Pharmacology. 2007 Jul;72(1):52-61. PMID 17409284

Further reading

  • Zeiger JS, Haberstick BC, Schlaepfer I, et al. (2008). "The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.". Hum. Mol. Genet. 17 (5): 724–34. doi:10.1093/hmg/ddm344. PMID 18055561.  
  • Shi J, Hattori E, Zou H, et al. (2007). "No evidence for association between 19 cholinergic genes and bipolar disorder.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (6): 715–23. doi:10.1002/ajmg.b.30417. PMID 17373692.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Keiger CJ, Case LD, Kendal-Reed M, et al. (2003). "Nicotinic cholinergic receptor expression in the human nasal mucosa.". Ann. Otol. Rhinol. Laryngol. 112 (1): 77–84. PMID 12537063.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ebihara M, Ohba H, Ohno SI, Yoshikawa T (2003). "Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression.". Gene 298 (1): 101–8. doi:10.1016/S0378-1119(02)00925-3. PMID 12406580.  
  • Graham A, Court JA, Martin-Ruiz CM, et al. (2002). "Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum.". Neuroscience 113 (3): 493–507. doi:10.1016/S0306-4522(02)00223-3. PMID 12150770.  
  • Le Novère N, Zoli M, Changeux JP (1997). "Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain.". Eur. J. Neurosci. 8 (11): 2428–39. doi:10.1111/j.1460-9568.1996.tb01206.x. PMID 8950106.  
  • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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