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Chloride channel 3
Symbols CLCN3; CLC3; ClC-3
External IDs OMIM600580 MGI103555 HomoloGene20435 GeneCards: CLCN3 Gene
RNA expression pattern
PBB GE CLCN3 201734 at tn.png
PBB GE CLCN3 201732 s at tn.png
PBB GE CLCN3 201733 at tn.png
More reference expression data
Species Human Mouse
Entrez 1182 12725
Ensembl ENSG00000109572 ENSMUSG00000004319
UniProt P51790 Q6PEV2
RefSeq (mRNA) NM_001829 NM_007711
RefSeq (protein) NP_001820 NP_031737
Location (UCSC) Chr 4:
170.78 - 170.88 Mb
Chr 8:
63.8 - 63.88 Mb
PubMed search [1] [2]

H(+)/Cl(-) exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene.[1]



CLCN3 has been shown to interact with PDZK1.[2]

See also


  1. ^ "Entrez Gene: CLCN3 chloride channel 3".  
  2. ^ Gentzsch, Martina; Cui Liying, Mengos April, Chang Xiu-Bao, Chen Jey-Hsin, Riordan John R (Feb. 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. (United States) 278 (8): 6440–9. doi:10.1074/jbc.M211050200. ISSN 0021-9258. PMID 12471024.  

Further reading

  • Borsani G, Rugarli EI, Taglialatela M, et al. (1995). "Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein.". Genomics 27 (1): 131–41. doi:10.1006/geno.1995.1015. PMID 7665160.  
  • Taine L, Coupry I, Boisseau P, et al. (1998). "Refined localisation of the voltage-gated chloride channel, CLCN3, to 4q33.". Hum. Genet. 102 (2): 178–81. doi:10.1007/s004390050673. PMID 9521585.  
  • Shepard AR, Rae JL (1998). "Ion transporters and receptors in cDNA libraries from lens and cornea epithelia.". Curr. Eye Res. 17 (7): 708–19. doi:10.1080/02713689808951247. PMID 9678416.  
  • Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome.". EMBO J. 17 (23): 6879–87. doi:10.1093/emboj/17.23.6879. PMID 9843494.  
  • Lamb FS, Clayton GH, Liu BX, et al. (1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels.". J. Mol. Cell. Cardiol. 31 (3): 657–66. doi:10.1006/jmcc.1998.0901. PMID 10198195.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Huang P, Liu J, Di A, et al. (2001). "Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase.". J. Biol. Chem. 276 (23): 20093–100. doi:10.1074/jbc.M009376200. PMID 11274166.  
  • Lamb FS, Graeff RW, Clayton GH, et al. (2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.". Am. J. Respir. Cell Mol. Biol. 24 (4): 376–81. PMID 11306429.  
  • Ogura T, Furukawa T, Toyozaki T, et al. (2002). "ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC.". FASEB J. 16 (8): 863–5. doi:10.1096/fj.01-0845fje. PMID 11967229.  
  • Hermoso M, Satterwhite CM, Andrade YN, et al. (2002). "ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl- channels and volume regulation in HeLa cells and Xenopus laevis oocytes.". J. Biol. Chem. 277 (42): 40066–74. doi:10.1074/jbc.M205132200. PMID 12183454.  
  • Gentzsch M, Cui L, Mengos A, et al. (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins.". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Jin NG, Kim JK, Yang DK, et al. (2003). "Fundamental role of ClC-3 in volume-sensitive Cl- channel function and cell volume regulation in AGS cells.". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (5): G938–48. doi:10.1152/ajpgi.00470.2002. PMID 12842831.  
  • Olsen ML, Schade S, Lyons SA, et al. (2003). "Expression of voltage-gated chloride channels in human glioma cells.". J. Neurosci. 23 (13): 5572–82. PMID 12843258.  
  • Salazar G, Love R, Styers ML, et al. (2004). "AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells.". J. Biol. Chem. 279 (24): 25430–9. doi:10.1074/jbc.M402331200. PMID 15073168.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Zhou JG, Ren JL, Qiu QY, et al. (2005). "Regulation of intracellular Cl- concentration through volume-regulated ClC-3 chloride channels in A10 vascular smooth muscle cells.". J. Biol. Chem. 280 (8): 7301–8. doi:10.1074/jbc.M412813200. PMID 15596438.  
  • Yeung CH, Barfield JP, Cooper TG (2006). "Chloride channels in physiological volume regulation of human spermatozoa.". Biol. Reprod. 73 (5): 1057–63. doi:10.1095/biolreprod.105.044123. PMID 16033995.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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