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Chloride intracellular channel 1

PDB rendering based on 1k0m.
Available structures
1k0m, 1k0n, 1k0o, 1rk4
Symbols CLIC1; G6; NCC27
External IDs OMIM602872 MGI2148924 HomoloGene20343 GeneCards: CLIC1 Gene
RNA expression pattern
PBB GE CLIC1 208659 at tn.png
More reference expression data
Species Human Mouse
Entrez 1192 114584
Ensembl ENSG00000096238 ENSMUSG00000007041
UniProt O00299 Q3TIP8
RefSeq (mRNA) NM_001288 NM_033444
RefSeq (protein) NP_001279 NP_254279
Location (UCSC) Chr c6_COX:
31.83 - 31.84 Mb
Chr 17:
34.66 - 34.67 Mb
PubMed search [1] [2]

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.[1][2]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.[2]



CLIC1 has been shown to interact with TRAPPC2.[3]

See also


  1. ^ Valenzuela SM, Martin DK, Por SB, Robbins JM, Warton K, Bootcov MR, Schofield PR, Campbell TJ, Breit SN (Jun 1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J Biol Chem 272 (19): 12575–82. PMID 9139710.  
  2. ^ a b "Entrez Gene: CLIC1 chloride intracellular channel 1".  
  3. ^ Fan, Libin; Yu Wei, Zhu Xueliang (Apr. 2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. (Netherlands) 540 (1-3): 77–80. ISSN 0014-5793. PMID 12681486.  

Further reading

  • Okubo K, Hori N, Matoba R, et al. (1994). "Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression.". Nat. Genet. 2 (3): 173–9. doi:10.1038/ng1192-173. PMID 1345164.  
  • Frigerio JM, Berthézène P, Garrido P, et al. (1995). "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing.". Hum. Mol. Genet. 4 (1): 37–43. doi:10.1093/hmg/4.1.37. PMID 7711732.  
  • Liew CC, Hwang DM, Fung YW, et al. (1994). "A catalogue of genes in the cardiovascular system as identified by expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10645–9. doi:10.1073/pnas.91.22.10645. PMID 7938007.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Heiss NS, Poustka A (1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.". Genomics 45 (1): 224–8. doi:10.1006/geno.1997.4922. PMID 9339381.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Tulk BM, Edwards JC (1998). "NCC27, a homolog of intracellular Cl- channel p64, is expressed in brush border of renal proximal tubule.". Am. J. Physiol. 274 (6 Pt 2): F1140–9. PMID 9841507.  
  • Chuang JZ, Milner TA, Zhu M, Sung CH (1999). "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.". J. Neurosci. 19 (8): 2919–28. PMID 10191309.  
  • Ribas G, Neville M, Wixon JL, et al. (1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.". J. Immunol. 163 (1): 278–87. PMID 10384126.  
  • Berryman M, Bretscher A (2000). "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.". Mol. Biol. Cell 11 (5): 1509–21. PMID 10793131.  
  • Tonini R, Ferroni A, Valenzuela SM, et al. (2000). "Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells.". FASEB J. 14 (9): 1171–8. PMID 10834939.  
  • Valenzuela SM, Mazzanti M, Tonini R, et al. (2001). "The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.". J. Physiol. (Lond.) 529 Pt 3: 541–52. PMID 11195932.  
  • Harrop SJ, DeMaere MZ, Fairlie WD, et al. (2002). "Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.". J. Biol. Chem. 276 (48): 44993–5000. doi:10.1074/jbc.M107804200. PMID 11551966.  
  • Warton K, Tonini R, Fairlie WD, et al. (2002). "Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1.". J. Biol. Chem. 277 (29): 26003–11. doi:10.1074/jbc.M203666200. PMID 11978800.  
  • Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins.". FEBS Lett. 540 (1-3): 77–80. doi:10.1016/S0014-5793(03)00228-X. PMID 12681486.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Littler DR, Harrop SJ, Fairlie WD, et al. (2004). "The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.". J. Biol. Chem. 279 (10): 9298–305. doi:10.1074/jbc.M308444200. PMID 14613939.  
  • Singh H, Ashley RH (2006). "Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore.". Biophys. J. 90 (5): 1628–1638. doi:10.1529/biophysj.105.072678. PMID 16339885.  
  • Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin.". FEBS J. 274 (24): 6306–6316. PMID 18028448.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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