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Chloride intracellular channel 2
Symbols CLIC2; CLIC2b; XAP121
External IDs OMIM300138 HomoloGene48010 GeneCards: CLIC2 Gene
RNA expression pattern
PBB GE CLIC2 213415 at tn.png
More reference expression data
Species Human Mouse
Entrez 1193 n/a
Ensembl ENSG00000155962 n/a
UniProt O15247 n/a
RefSeq (mRNA) NM_001289 n/a
RefSeq (protein) NP_001280 n/a
Location (UCSC) Chr X:
154.16 - 154.22 Mb
PubMed search [1] n/a

Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.[1][2]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.[2]


See also


  1. ^ Heiss NS, Poustka A (Nov 1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics 45 (1): 224-8. doi:10.1006/geno.1997.4922. PMID 9339381.  
  2. ^ a b "Entrez Gene: CLIC2 chloride intracellular channel 2".  

Further reading

  • Thiemann A, Gründer S, Pusch M, Jentsch TJ (1992). "A chloride channel widely expressed in epithelial and non-epithelial cells.". Nature 356 (6364): 57–60. doi:10.1038/356057a0. PMID 1311421.  
  • Rogner UC, Heiss NS, Kioschis P, et al. (1997). "Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28.". Genome Res. 6 (10): 922–34. doi:10.1101/gr.6.10.922. PMID 8908511.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Dhani SU, Mohammad-Panah R, Ahmed N, et al. (2003). "Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex.". J. Biol. Chem. 278 (18): 16262–70. doi:10.1074/jbc.M209828200. PMID 12601004.  
  • Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins.". FEBS Lett. 540 (1-3): 77–80. doi:10.1016/S0014-5793(03)00228-X. PMID 12681486.  
  • Board PG, Coggan M, Watson S, et al. (2005). "CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.". Int. J. Biochem. Cell Biol. 36 (8): 1599–612. doi:10.1016/j.biocel.2004.01.026. PMID 15147738.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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