The Full Wiki

More info on CLIC5

CLIC5: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Chloride intracellular channel 5
Symbols CLIC5; CLIC5B; FLJ90663; MST130; MSTP130; dJ447E21.4
External IDs OMIM607293 MGI1917912 HomoloGene987 GeneCards: CLIC5 Gene
RNA expression pattern
PBB GE CLIC5 219866 at tn.png
PBB GE CLIC5 217628 at tn.png
More reference expression data
Species Human Mouse
Entrez 53405 224796
Ensembl ENSG00000112782 ENSMUSG00000023959
UniProt Q9NZA1 Q8BXK9
RefSeq (mRNA) NM_016929 NM_172621
RefSeq (protein) NP_058625 NP_766209
Location (UCSC) Chr 6:
45.98 - 46.16 Mb
Chr 17:
43.65 - 43.74 Mb
PubMed search [1] [2]

Chloride intracellular channel protein 5 is a protein that in humans is encoded by the CLIC5 gene.[1][2] Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 specifically associates with the cytoskeleton of placenta microvilli.[supplied by OMIM][2]It can form ion channel in bilayers and is regulated by actin.


See also


Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.  
  • Suzuki T, Morita R, Sugimoto Y, et al. (2002). "Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5.". Epilepsy Res. 50 (3): 265–75. doi:10.1016/S0920-1211(02)00052-9. PMID 12200217.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Berryman M, Bruno J, Price J, Edwards JC (2004). "CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.". J. Biol. Chem. 279 (33): 34794–801. doi:10.1074/jbc.M402835200. PMID 15184393.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  
  • Gonzalez A, Ciobanu D, Sayers M, et al. (2007). "Gene transcript amplification from cell lysates in continuous-flow microfluidic devices.". Biomedical microdevices 9 (5): 729–36. doi:10.1007/s10544-007-9083-1. PMID 17492382.  
  • Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin.". FEBS J. 274 (24): 6306–6316. PMID 18028448.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address