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Chloride intracellular channel 6
Symbols CLIC6; CLIC1L
External IDs MGI2146607 HomoloGene43154 GeneCards: CLIC6 Gene
Species Human Mouse
Entrez 54102 209195
Ensembl ENSG00000159212 ENSMUSG00000022949
UniProt Q96NY7 Q8BHB9
RefSeq (mRNA) NM_053277 NM_172469
RefSeq (protein) NP_444507 NP_766057
Location (UCSC) Chr 21:
34.96 - 35.01 Mb
Chr 16:
92.39 - 92.43 Mb
PubMed search [1] [2]

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[1][2]

This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[2]



CLIC6 has been shown to interact with Dopamine receptor D3.[3]

See also


  1. ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.  
  2. ^ a b "Entrez Gene: CLIC6 chloride intracellular channel 6".  
  3. ^ Griffon, Nathalie; Jeanneteau Freddy, Prieur Fanny, Diaz Jorge, Sokoloff Pierre (Sep. 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. (Netherlands) 117 (1): 47–57. ISSN 0169-328X. PMID 14499480.  

Further reading

  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.  
  • Strippoli P, D'Addabbo P, Lenzi L, et al. (2003). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q.". Mamm. Genome 13 (8): 456–62. doi:10.1007/s00335-001-2157-0. PMID 12226712.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. PMID 12747765.  
  • Griffon N, Jeanneteau F, Prieur F, et al. (2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.". Brain Res. Mol. Brain Res. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480.  
  • Friedli M, Guipponi M, Bertrand S, et al. (2004). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12.". Gene 320: 31–40. doi:10.1016/S0378-1119(03)00830-8. PMID 14597386.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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