The CLIX wheel retention system is a 2006 re-invention of the [Campagnolo] [Quick release skewer] by [Montague Inventive Technologies].
It is designed to be less susceptible to user error as there is just one way to fasten the skewer.
The system requires modified dropouts to work properly so the axle "clicks" into position when the wheel is put on the bike.
The fastening lever is then tightened similar to the normal Quick release.
A limiting factor is that the same wheel cannot be easily swapped into used on another bike with different thickness dropouts.

Here is the company's media release.
<blockquote>
CAMBRIDGE, MA – CLIX Wheel Release Sytems™ announced a revolutionary new wheel release system, called
CLIX™. For the first time ever, riders are able to easily install and lock their front wheel with no cam adjustment, and
with only one hand. This innovative quick release has a back-up safety catch that locks into place when the wheel is
installed into the fork; the rider knows the wheel is installed properly when they hear the audible “click” from the locking
mechanism. Then the rider simply closes the quick release lever.
The traditional quick release was invented in 1927 and is a safe and effective system when operated correctly.
However, correct operation is not inherently obvious to all riders. The problem occurs when the rider spins the quick
release lever like a ‘wing nut’ until it is tightened, rather than operating it properly like a quick release cam. This gives
the impression that the wheel is safely fastened when it is not. With the new CLIX system, the rider does not need to
tighten the system by turning it. The rider simply closes the lever in one motion. And if the rider forgets to close the
quick release lever, the primary form of retention, the wheel has a secondary retention system.
The C.E.O. of Pacific Cycle, North America's largest bicycle company, states that CLIX’s is “… the greatest advance
in wheel removal and retention the bicycle industry has seen since the invention of the traditional quick release
system.” CLIX is now being shipped to dealers worldwide. The award winning CLIX� system is designed to make the
front wheel quick release easier, and more intuitive to use. Riders can now remove the front wheel with one hand -
with no spinning of the adjustment nut. President, David Montague, states “There will be a very short learning curve
for retailers and cyclist because the CLIX system is very similar in design from traditional quick releases and is more
intuitive to use."
Once the dealer has properly adjusted CLIX, no quick release adjustment is required each time the wheel is removed
and installed. There are worldwide patents pending on the CLIX system.
CLIX Wheel Release Systems is based in Cambridge, Massachusetts and is dedicated to advancing cycling through
the development of inventive technologies that provide its customers with an unprecedented combination of
performance and convenience. Visit www.clixqr.com or call toll free 1-800-736-5348 for more information.
</blockquote>.