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CLNS1A: Wikis


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Chloride channel, nucleotide-sensitive, 1A

PDB rendering based on 1zyi.
Available structures
Symbols CLNS1A; CLNS1B; ICln; CLCI
External IDs OMIM602158 MGI109638 HomoloGene990 GeneCards: CLNS1A Gene
RNA expression pattern
PBB GE CLNS1A 209143 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1207 12729
Ensembl ENSG00000074201 ENSMUSG00000025439
UniProt P54105 P97506
RefSeq (mRNA) NM_001293 NM_023671
RefSeq (protein) NP_001284 NP_076160
Location (UCSC) Chr 11:
77 - 77.03 Mb
Chr 7:
97.57 - 97.59 Mb
PubMed search [1] [2]

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.[1][2][3]



CLNS1A has been shown to interact with Small nuclear ribonucleoprotein D1,[4] ITGA2B,[5] SNRPD3[4] and Protein arginine methyltransferase 5.[6][4][7]

See also


  1. ^ Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun 208 (1): 89–95. PMID 7887970.  
  2. ^ Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics 38 (3): 438–41. doi:10.1006/geno.1996.0651. PMID 8975725.  
  3. ^ "Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A".  
  4. ^ a b c Friesen, W J; Paushkin S, Wyce A, Massenet S, Pesiridis G S, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec. 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. (United States) 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. ISSN 0270-7306. PMID 11713266.  
  5. ^ Larkin, Deirdre; Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun. 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. (United States) 279 (26): 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.  
  6. ^ Krapivinsky, G; Pu W, Wickman K, Krapivinsky L, Clapham D E (May. 1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology". J. Biol. Chem. (UNITED STATES) 273 (18): 10811–4. ISSN 0021-9258. PMID 9556550.  
  7. ^ Friesen, Westley J; Wyce Anastasia, Paushkin Sergey, Abel Linda, Rappsilber Juri, Mann Matthias, Dreyfuss Gideon (Mar. 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. (United States) 277 (10): 8243–7. doi:10.1074/jbc.M109984200. ISSN 0021-9258. PMID 11756452.  

Further reading

  • Calinisan V, Gravem D, Chen RP, et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.". Front. Biosci. 11: 1646–66. doi:10.2741/1911. PMID 16368544.  
  • Buyse G, de Greef C, Raeymaekers L, et al. (1996). "The ubiquitously expressed pICln protein forms homomeric complexes in vitro.". Biochem. Biophys. Res. Commun. 218 (3): 822–7. doi:10.1006/bbrc.1996.0146. PMID 8579598.  
  • Schwartz RS, Rybicki AC, Nagel RL (1997). "Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin.". Biochem. J. 327 ( Pt 2): 609–16. PMID 9359436.  
  • Bekri S, Adélaïde J, Merscher S, et al. (1998). "Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma.". Cytogenet. Cell Genet. 79 (1-2): 125–31. doi:10.1159/000134699. PMID 9533029.  
  • Krapivinsky G, Pu W, Wickman K, et al. (1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology.". J. Biol. Chem. 273 (18): 10811–4. doi:10.1074/jbc.273.18.10811. PMID 9556550.  
  • Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation.". Blood 92 (4): 1442–7. PMID 9694734.  
  • Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE (1999). "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins.". Mol. Cell. Biol. 19 (6): 4113–20. PMID 10330151.  
  • Hubert MD, Levitan I, Hoffman MM, et al. (2000). "Modulation of volume regulated anion current by I(Cln).". Biochim. Biophys. Acta 1466 (1-2): 105–14. doi:10.1016/S0005-2736(00)00177-2. PMID 10825435.  
  • Friesen WJ, Paushkin S, Wyce A, et al. (2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMID 11713266.  
  • Meister G, Eggert C, Bühler D, et al. (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.". Curr. Biol. 11 (24): 1990–4. doi:10.1016/S0960-9822(01)00592-9. PMID 11747828.  
  • Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins.". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Meyer G, Rodighiero S, Guizzardi F, et al. (2004). "Volume-regulated Cl- channels in human pleural mesothelioma cells.". FEBS Lett. 559 (1-3): 45–50. doi:10.1016/S0014-5793(04)00020-1. PMID 14960305.  
  • Larkin D, Murphy D, Reilly DF, et al. (2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation.". J. Biol. Chem. 279 (26): 27286–93. doi:10.1074/jbc.M402159200. PMID 15075326.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Fürst J, Schedlbauer A, Gandini R, et al. (2005). "ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.". J. Biol. Chem. 280 (35): 31276–82. doi:10.1074/jbc.M500541200. PMID 15905169.  
  • Azzouz TN, Pillai RS, Däpp C, et al. (2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.". J. Biol. Chem. 280 (41): 34435–40. doi:10.1074/jbc.M505077200. PMID 16087681.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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