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Nuclear receptor subfamily 2, group F, member 2
Identifiers
Symbols NR2F2; ARP1; COUP-TFII; COUPTFB; MGC117452; SVP40; TFCOUP2
External IDs OMIM107773 MGI1352452 HomoloGene7628 GeneCards: NR2F2 Gene
RNA expression pattern
PBB GE NR2F2 209120 at tn.png
PBB GE NR2F2 209121 x at tn.png
PBB GE NR2F2 215073 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7026 11819
Ensembl ENSG00000185551 ENSMUSG00000030551
UniProt P24468 Q3UST6
RefSeq (mRNA) NM_021005 NM_009697
RefSeq (protein) NP_066285 NP_033827
Location (UCSC) Chr 15:
94.67 - 94.68 Mb
Chr 7:
70.23 - 70.24 Mb
PubMed search [1] [2]

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.[1] The COUP acronym stands for chicken ovalbumin upstream promoter.

Contents

Function

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.[2][3]

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity.[4][5] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.[6]

Interactions

COUP-TFII has been shown to interact with HDAC1,[7] V-erbA-related gene[8] and Lck.[9]

References

  1. ^ "Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7026. 
  2. ^ Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development". Genes Dev. 13 (8): 1037–49. doi:10.1128/MCB.24.24.10835-10843.2004. PMID 10215630. 
  3. ^ Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (December 2004). "The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development". Mol. Cell. Biol. 24 (24): 10835–43. doi:10.1128/MCB.24.24.10835-10843.2004. PMID 15572686. 
  4. ^ De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (April 2004). "The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism". Mol. Endocrinol. 18 (4): 820–33. doi:10.1210/me.2003-0341. PMID 14739255. 
  5. ^ De Martino MU, Alesci S, Chrousos GP, Kino T (June 2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024: 72–85. doi:10.1196/annals.1321.006. PMID 15265774. 
  6. ^ Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (February 2008). "The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis". Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421–6. doi:10.1073/pnas.0707082105. PMID 18250317. 
  7. ^ Smirnov, D A; Hou S, Ricciardi R P (Mar. 2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology (UNITED STATES) 268 (2): 319–28. doi:10.1006/viro.1999.0181. ISSN 0042-6822. PMID 10704340. 
  8. ^ Avram, D; Ishmael J E, Nevrivy D J, Peterson V J, Lee S H, Dowell P, Leid M (May. 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". J. Biol. Chem. (UNITED STATES) 274 (20): 14331–6. ISSN 0021-9258. PMID 10318855. 
  9. ^ Marcus, S L; Winrow C J, Capone J P, Rachubinski R A (Nov. 1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. (UNITED STATES) 271 (44): 27197–200. ISSN 0021-9258. PMID 8910285. 

Further reading

  • De Martino MU, Alesci S, Chrousos GP, Kino T (2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism.". Ann. N. Y. Acad. Sci. 1024: 72–85. doi:10.1196/annals.1321.006. PMID 15265774. 
  • Mietus-Snyder M, Sladek FM, Ginsburg GS, et al. (1992). "Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.". Mol. Cell. Biol. 12 (4): 1708–18. PMID 1312668. 
  • Wang LH, Ing NH, Tsai SY, et al. (1992). "The COUP-TFs compose a family of functionally related transcription factors.". Gene Expr. 1 (3): 207–16. PMID 1820218. 
  • Ladias JA, Karathanasis SK (1991). "Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily.". Science 251 (4993): 561–5. doi:10.1126/science.1899293. PMID 1899293. 
  • Qiu Y, Krishnan V, Zeng Z, et al. (1996). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.". Genomics 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078. 
  • Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor.". J. Biol. Chem. 271 (44): 27197–200. doi:10.1074/jbc.271.44.27197. PMID 8910285. 
  • Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.". J. Biol. Chem. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274. 
  • Chu K, Zingg HH (1998). "The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter.". J. Mol. Endocrinol. 19 (2): 163–72. doi:10.1677/jme.0.0190163. PMID 9343308. 
  • Bailey P, Sartorelli V, Hamamori Y, Muscat GE (1999). "The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD.". Nucleic Acids Res. 26 (23): 5501–10. doi:10.1093/nar/26.23.5501. PMID 9826778. 
  • Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMID 10318855. 
  • Smirnov DA, Hou S, Ricciardi RP (2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription.". Virology 268 (2): 319–28. doi:10.1006/viro.1999.0181. PMID 10704340. 
  • Avram D, Fields A, Pretty On Top K, et al. (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMID 10744719. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Jordan EM, Worley T, Breen GA (2003). "Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1.". Biochemistry 42 (9): 2656–63. doi:10.1021/bi0268347. PMID 12614160. 
  • Sato Y, Suzuki T, Hidaka K, et al. (2003). "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle.". J. Clin. Endocrinol. Metab. 88 (7): 3415–20. doi:10.1210/jc.2002-021723. PMID 12843196. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kurihara I, Shibata H, Kobayashi S, et al. (2005). "Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.". J. Biol. Chem. 280 (8): 6721–30. doi:10.1074/jbc.M411820200. PMID 15611122. 
  • Shibata H, Kobayashi S, Kurihara I, et al. (2005). "COUP-TF and transcriptional co-regulators in adrenal steroidogenesis.". Endocr. Res. 30 (4): 795–801. doi:10.1081/ERC-200044042. PMID 15666827. 
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