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CP-154,526
CP154526.svg
IUPAC name
Identifiers
CAS number 157286-86-7
PubChem 5311055
SMILES
Properties
Molecular formula C23H32N4
Molar mass 364.52698
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

CP-154,526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer.[1]

CP-154,526 is under investigation for the potential treatment of alcoholism. [2][3]

See also

References

  1. ^ Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD 3rd, Winston EN, Chen YL, Heym J (September 1996). "CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10477–82. doi:10.1073/pnas.93.19.10477. PMID 8816826. PMC 38410. http://www.pnas.org/content/93/19/10477.abstract.  
  2. ^ "Drug Has Potential To Prevent Alcoholics From Relapsing". Science News. ScienceDaily. 2008-08-02. http://www.sciencedaily.com/releases/2008/07/080730175518.htm. Retrieved 2008-08-09.  
  3. ^ Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ (July 2008). "Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism". Proc. Natl. Acad. Sci. U.S.A. 105 (26): 9070–5. doi:10.1073/pnas.0710181105. PMID 18591672.  

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