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CP-809,101
Systematic (IUPAC) name
2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine
Identifiers
CAS number 479683-64-2
ATC code  ?
PubChem  ?
Chemical data
Formula C 15H17ClN4O 
Mol. mass 304.774 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

CP-809,101 is a drug which acts as a potent and selective 5-HT2C receptor agonist.[1] It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.[2][3]

References

  1. ^ Strong PV, Greenwood BN, Fleshner M (May 2009). "The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats". Psychopharmacology 203 (4): 665–75. doi:10.1007/s00213-008-1413-3. PMID 19037632.  
  2. ^ Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA (February 2007). "CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity". Neuropharmacology 52 (2): 279–90. doi:10.1016/j.neuropharm.2006.07.024. PMID 16949622.  
  3. ^ Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K (June 2007). "Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation". Drug Metabolism and Disposition: the Biological Fate of Chemicals 35 (6): 848–58. doi:10.1124/dmd.106.013649. PMID 17344339.  
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