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CAMP responsive element binding protein 3
Symbols CREB3; LUMAN; LZIP; MGC15333; MGC19782
External IDs OMIM606443 MGI99946 HomoloGene31375 GeneCards: CREB3 Gene
RNA expression pattern
PBB GE CREB3 209432 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10488 12913
Ensembl ENSG00000107175 ENSMUSG00000028466
UniProt O43889 Q61817
RefSeq (mRNA) NM_006368 NM_013497
RefSeq (protein) NP_006359 NP_038525
Location (UCSC) Chr 9:
35.72 - 35.73 Mb
Chr 4:
43.58 - 43.59 Mb
PubMed search [1] [2]

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.[1][2]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.[2]


See also


CREB3 has been shown to interact with Host cell factor C1.[3][4]


  1. ^ Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol 17 (9): 5117–26. PMID 9271389.  
  2. ^ a b "Entrez Gene: CREB3 cAMP responsive element binding protein 3".  
  3. ^ Lu, R; Yang P, Padmakumar S, Misra V (Aug. 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. (UNITED STATES) 72 (8): 6291–7. ISSN 0022-538X. PMID 9658067.  
  4. ^ Freiman, R N; Herr W (Dec. 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. (UNITED STATES) 11 (23): 3122–7. ISSN 0890-9369. PMID 9389645.  

Further reading

  • Freiman RN, Herr W (1998). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.". Genes Dev. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. PMID 9389645.  
  • Lu R, Yang P, Padmakumar S, Misra V (1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF.". J. Virol. 72 (8): 6291–7. PMID 9658067.  
  • Lu R, Misra V (2000). "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency.". J. Virol. 74 (2): 934–43. doi:10.1128/JVI.74.2.934-943.2000. PMID 10623756.  
  • Mahajan SS, Wilson AC (2000). "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP.". Mol. Cell. Biol. 20 (3): 919–28. doi:10.1128/MCB.20.3.919-928.2000. PMID 10629049.  
  • Jin DY, Wang HL, Zhou Y, et al. (2000). "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation.". Embo J. 19 (4): 729–40. doi:10.1093/emboj/19.4.729. PMID 10675342.  
  • Luciano RL, Wilson AC (2000). "N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif.". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10757–62. doi:10.1073/pnas.190062797. PMID 10984507.  
  • Raggo C, Rapin N, Stirling J, et al. (2002). "Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis.". Mol. Cell. Biol. 22 (16): 5639–49. doi:10.1128/MCB.22.16.5639-5649.2002. PMID 12138176.  
  • Mahajan SS, Little MM, Vazquez R, Wilson AC (2003). "Interaction of HCF-1 with a cellular nuclear export factor.". J. Biol. Chem. 277 (46): 44292–9. doi:10.1074/jbc.M205440200. PMID 12235138.  
  • Luciano RL, Wilson AC (2002). "An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13403–8. doi:10.1073/pnas.202200399. PMID 12271126.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ko J, Jang SW, Kim YS, et al. (2004). "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines.". Faseb J. 18 (7): 890–2. doi:10.1096/fj.03-0867fje. PMID 15001559.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Misra V, Rapin N, Akhova O, et al. (2005). "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman.". J. Biol. Chem. 280 (15): 15257–66. doi:10.1074/jbc.M500728200. PMID 15705566.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Liang G, Audas TE, Li Y, et al. (2007). "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.". Mol. Cell. Biol. 26 (21): 7999–8010. doi:10.1128/MCB.01046-06. PMID 16940180.  
  • Blot G, Lopez-Vergès S, Treand C, et al. (2007). "Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR.". J. Mol. Biol. 364 (5): 1034–47. doi:10.1016/j.jmb.2006.09.080. PMID 17054986.  
  • Jang SW, Kim YS, Lee YH, Ko J (2007). "Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines.". J. Cell. Physiol. 211 (3): 630–7. doi:10.1002/jcp.20968. PMID 17192849.  
  • Jang SW, Kim YS, Kim YR, et al. (2007). "Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1.". J. Biol. Chem. 282 (15): 11092–100. doi:10.1074/jbc.M607962200. PMID 17296613.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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