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CREB regulated transcription coactivator 2
Identifiers
Symbols CRTC2; RP11-422P24.6; TORC2
External IDs OMIM608972 MGI1921593 HomoloGene18765 GeneCards: CRTC2 Gene
Orthologs
Species Human Mouse
Entrez 200186 74343
Ensembl ENSG00000160741 ENSMUSG00000027936
UniProt n/a n/a
RefSeq (mRNA) NM_181715 NM_028881
RefSeq (protein) NP_859066 NP_083157
Location (UCSC) Chr 1:
152.19 - 152.2 Mb
Chr 3:
90.34 - 90.35 Mb
PubMed search [1] [2]

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[1][2][3]

Contents

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[4]

Interactions

CRTC2 has been shown to interact with SNF1LK2[5] and YWHAQ.[5][6]

References

  1. ^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200186.  
  2. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMID 14506290.  
  3. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Mol. Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.  
  4. ^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". Bioessays 28 (3): 231–4. doi:10.1002/bies.20375. PMID 16479585.  
  5. ^ a b Screaton, Robert A; Conkright Michael D, Katoh Yoshiko, Best Jennifer L, Canettieri Gianluca, Jeffries Shawn, Guzman Ernesto, Niessen Sherry, Yates John R, Takemori Hiroshi, Okamoto Mitsuhiro, Montminy Marc (Oct. 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell (United States) 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. ISSN 0092-8674. PMID 15454081.  
  6. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3: 89. doi:10.1038/msb4100134. PMID 17353931.  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Iourgenko V, Zhang W, Mickanin C, et al. (2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMID 14506290.  
  • Conkright MD, Canettieri G, Screaton R, et al. (2003). "TORCs: transducers of regulated CREB activity.". Mol. Cell 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.  
  • Screaton RA, Conkright MD, Katoh Y, et al. (2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.". Cell 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.  
  • Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.". J. Cell. Sci. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.  
  • Siu YT, Chin KT, Siu KL, et al. (2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats.". J. Virol. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMID 16809310.  
  • Wu Z, Huang X, Feng Y, et al. (2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.". Proc. Natl. Acad. Sci. U.S.A. 103 (39): 14379–84. doi:10.1073/pnas.0606714103. PMID 16980408.  
  • Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMID 17043309.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  
  • Ravnskjaer K, Kester H, Liu Y, et al. (2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.". Embo J. 26 (12): 2880–9. doi:10.1038/sj.emboj.7601715. PMID 17476304.  
  • Kuraishy AI, French SW, Sherman M, et al. (2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation.". Proc. Natl. Acad. Sci. U.S.A. 104 (24): 10175–80. doi:10.1073/pnas.0704170104. PMID 17548807.  

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