The Full Wiki

CUTL1: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Cut-like 1, CCAAT displacement protein (Drosophila)
Symbols CUTL1; CASP; CDP; COY1; CUX; Nbla10317; p100; p110; p200; p75
External IDs OMIM116896 MGI88568 HomoloGene22551 GeneCards: CUTL1 Gene
Species Human Mouse
Entrez 1523 13047
Ensembl ENSG00000160967 ENSMUSG00000029705
UniProt P39880 P70381
RefSeq (mRNA) NM_001913 NM_009986
RefSeq (protein) NP_001904 NP_034116
Location (UCSC) Chr 7:
101.25 - 101.71 Mb
Chr 5:
136.53 - 136.85 Mb
PubMed search [1] [2]

Protein CASP is a protein that in humans is encoded by the CUX1 gene.[1][2][3][4]

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[4]



CUTL1 has been shown to interact with CREB binding protein,[5] SATB1[6] and Retinoblastoma protein.[7]


  1. ^ Scherer SW, Neufeld EJ, Lievens PM, Orkin SH, Kim J, Tsui LC (May 1993). "Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids". Genomics 15 (3): 695–6. doi:10.1006/geno.1993.1130. PMID 8468066.  
  2. ^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res 8 (10): 1060–73. PMID 9799793.  
  3. ^ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Mol Biol Cell 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMID 15004235.  
  4. ^ a b "Entrez Gene: CUTL1 cut-like 1, CCAAT displacement protein (Drosophila)".  
  5. ^ Li, S; Aufiero B, Schiltz R L, Walsh M J (Jun. 2000). "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (13): 7166–71. doi:10.1073/pnas.130028697. ISSN 0027-8424. PMID 10852958.  
  6. ^ Liu, J; Barnett A, Neufeld E J, Dudley J P (Jul. 1999). "Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation". Mol. Cell. Biol. (UNITED STATES) 19 (7): 4918–26. ISSN 0270-7306. PMID 10373541.  
  7. ^ Gupta, Sunita; Luong Mai X, Bleuming Sylvia A, Miele Angela, Luong Michael, Young Daniel, Knudsen Erik S, Van Wijnen Andre J, Stein Janet L, Stein Gary S (Sep. 2003). "Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription". J. Cell. Physiol. (United States) 196 (3): 541–56. doi:10.1002/jcp.10335. ISSN 0021-9541. PMID 12891711.  

Further reading

  • Ottolenghi S, Mantovani R, Nicolis S, et al. (1990). "DNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobin.". Hemoglobin 13 (6): 523–41. doi:10.3109/03630268908993104. PMID 2481658.  
  • Nepveu A (2001). "Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development.". Gene 270 (1-2): 1–15. doi:10.1016/S0378-1119(01)00485-1. PMID 11403998.  
  • Neufeld EJ, Skalnik DG, Lievens PM, Orkin SH (1993). "Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut.". Nat. Genet. 1 (1): 50–5. doi:10.1038/ng0492-50. PMID 1301999.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan.". J. Biol. Chem. 271 (23): 13844–53. doi:10.1074/jbc.271.23.13844. PMID 8662884.  
  • Lievens PM, Tufarelli C, Donady JJ, et al. (1997). "CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro.". Gene 197 (1-2): 73–81. doi:10.1016/S0378-1119(97)00243-6. PMID 9332351.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Chattopadhyay S, Whitehurst CE, Chen J (1998). "A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression.". J. Biol. Chem. 273 (45): 29838–46. doi:10.1074/jbc.273.45.29838. PMID 9792700.  
  • Liu J, Barnett A, Neufeld EJ, Dudley JP (1999). "Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation.". Mol. Cell. Biol. 19 (7): 4918–26. PMID 10373541.  
  • Rong Zeng W, Soucie E, Sung Moon N, et al. (2000). "Exon/intron structure and alternative transcripts of the CUTL1 gene.". Gene 241 (1): 75–85. doi:10.1016/S0378-1119(99)00465-5. PMID 10607901.  
  • Martin-Soudant N, Drachman JG, Kaushansky K, Nepveu A (2000). "CDP/Cut DNA binding activity is down-modulated in granulocytes, macrophages and erythrocytes but remains elevated in differentiating megakaryocytes.". Leukemia 14 (5): 863–73. doi:10.1038/sj.leu.2401764. PMID 10803519.  
  • Li S, Aufiero B, Schiltz RL, Walsh MJ (2000). "Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7166–71. doi:10.1073/pnas.130028697. PMID 10852958.  
  • Nirodi C, Hart J, Dhawan P, et al. (2001). "The role of CDP in the negative regulation of CXCL1 gene expression.". J. Biol. Chem. 276 (28): 26122–31. doi:10.1074/jbc.M102872200. PMID 11371564.  
  • Moon NS, Premdas P, Truscott M, et al. (2001). "S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein.". Mol. Cell. Biol. 21 (18): 6332–45. doi:10.1128/MCB.21.18.6332-6345.2001. PMID 11509674.  
  • Santaguida M, Ding Q, Bérubé G, et al. (2002). "Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).". J. Biol. Chem. 276 (49): 45780–90. doi:10.1074/jbc.M107978200. PMID 11584018.  
  • Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address